Energetics of the HIV gp120-CD4 binding reaction

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1998 • 2,929 citations

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

Analytical ultracentrifugation in biochemistry and polymer science

1995 • 1,970 citations

The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

1999 • 1,932 citations

Coupling of Local Folding to Site-Specific Binding of Proteins to DNA

1994 • 1,382 citations

HIV Entry and Its Inhibition

1998 • 1,270 citations

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

The antigenic structure of the HIV gp120 envelope glycoprotein

1998 • 1,206 citations

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

1996 • 1,181 citations

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

1996 • 1,111 citations

[4] Circular dichroism

1995 • 1,000 citations

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

1993 • 636 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Thermodynamics of Structural Stability and Cooperative Folding Behavior in Proteins

1992 • 572 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Capture of an early fusion-active conformation of HIV-1 gp41

1998 • 490 citations

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

1997 • 474 citations

Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding

1995 • 414 citations

Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer.

1995 • 334 citations

[13] Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors

1998 • 309 citations

Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein

1996 • 307 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

Hydrophobic effect in protein folding and other noncovalent processes involving proteins.

1989 • 295 citations

Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein

1999 • 267 citations

Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies

1994 • 252 citations

Immobilization chemistries suitable for use in the BIAcore surface plasmon resonance detector

1992 • 247 citations

CLAMP©: a biosensor kinetic data analysis program

1998 • 217 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

HIV-1 neutralization: the consequences of viral adaptation to growth on transformed T cells.

1995 • 170 citations

Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication

1999 • 152 citations

The antibody response in HIV-1 infection.

1997 • 122 citations

Molecular basis of cooperativity in protein folding. V. Thermodynamic and structural conditions for the stabilization of compact denatured states

1994 • 117 citations

Why do we not have an HIV vaccine and how can we make one?

1998 • 112 citations

Probability Analysis of Variational Crystallization and Its Application to gp120, The Exterior Envelope Glycoprotein of Type 1 Human Immunodeficiency Virus (HIV-1)

1999 • 108 citations

Defining the structure and stability of macromolecular assemblies in solution: the re-emergence of analytical ultracentrifugation as a practical tool

1996 • 107 citations

Thermodynamics of Partly Folded Intermediates in Proteins

1995 • 106 citations

Envelope proteins from clinical isolates of human immunodeficiency virus type 1 that are refractory to neutralization by soluble CD4 possess high affinity for the CD4 receptor.

1991 • 94 citations

Regulated Expression Allows High Level Production and Secretion of HIV-1 gp120 Envelope Glycoprotein in Drosophila Schneider Cells

1991 • 91 citations

Conformational Changes of gp120 in Epitopes near the CCR5 Binding Site Are Induced by CD4 and a CD4 Miniprotein Mimetic

1999 • 91 citations

Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding

1996 • 60 citations

The Neuronal Progenitor Cells of the Forebrain Subventricular Zone: Intrinsic Propertiesin Vitroand Following Transplantation

1998 • 56 citations