Lung Cancer Chemoprevention

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis

2000 • 4,048 citations

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease

1996 • 3,608 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis

2000 • 3,176 citations

Cyclooxygenases: Structural, Cellular, and Molecular Biology

2000 • 2,837 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Nicotine replacement therapy for smoking cessation

2012 • 2,516 citations

Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

2005 • 2,476 citations

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

1996 • 2,429 citations

Final Report on the Aspirin Component of the Ongoing Physicians' Health Study

1989 • 2,180 citations

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

2005 • 2,039 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Smoking and Carcinoma of the Lung

1950 • 1,909 citations

Physician advice for smoking cessation

2013 • 1,851 citations

Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2006 • 1,630 citations

Cigarette Smoking Among Adults--United States, 2003

2005 • 1,531 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies

2000 • 1,391 citations

Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2006 • 1,343 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation

1997 • 1,273 citations

Randomised trial of prophylactic daily aspirin in British male doctors

1988 • 1,178 citations

Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer

2005 • 1,160 citations

Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer

2005 • 1,106 citations

Smoking cessation guidelines for health professionals: an update

2000 • 1,019 citations

TOBACCO SMOKING AS A POSSIBLE ETIOLOGIC FACTOR IN BRONCHIOGENIC CARCINOMA

1950 • 990 citations

The Mortality of Doctors in Relation to Their Smoking Habits

1954 • 915 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Recent Advances in Chemoprevention of Cancer

1997 • 837 citations

Smoking and Lung Cancer: Recent Evidence and a Discussion of Some Questions

1959 • 816 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Cigarette Smoking Among Adults, United States

2006 • 774 citations

Low-Dose Aspirin in the Primary Prevention of Cancer

2005 • 764 citations

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

1993 • 756 citations

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

1999 • 699 citations

Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression

2000 • 616 citations

Annual Report to the Nation on the Status of Cancer, 1973-1996, With a Special Section on Lung Cancer and Tobacco Smoking

1999 • 597 citations

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis

2000 • 511 citations

Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production.

1998 • 498 citations

Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis

2000 • 474 citations

β-Carotene Supplementation and Incidence of Cancer and Cardiovascular Disease: the Women's Health Study

1999 • 474 citations

Epidemiology of Lung Cancer: Looking to the Future

2005 • 473 citations

Targeting cyclooxygenase-2 in human neoplasia

2003 • 447 citations

Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.

1996 • 426 citations

Development of carcinoma of the lung as reflected in exfoliated cells

1974 • 422 citations

Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer.

2001 • 410 citations

EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer

2000 • 385 citations

Second Lung Cancers in Patients After Treatment for an Initial Lung Cancer

1998 • 378 citations

The Ki-67 Protein: Fascinating Forms and an Unknown Function

2000 • 372 citations

Initiating DNA synthesis: from recruiting to activating the MCM complex

2001 • 364 citations

Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

2005 • 352 citations

US public health service clinical practice guideline: treating tobacco use and dependence.

2000 • 348 citations

Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma

1999 • 333 citations

CANCER AND TOBACCO SMOKING

1950 • 322 citations

Randomized Phase III Intergroup Trial of Isotretinoin to Prevent Second Primary Tumors in Stage I Non-Small-Cell Lung Cancer

2001 • 318 citations

Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion

2002 • 261 citations

Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.

1998 • 259 citations

Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.

1996 • 252 citations

Non-small Cell Lung Cancer Cyclooxygenase-2-dependent Invasion Is Mediated by CD44

2001 • 240 citations

Pharmacotherapy for Nicotine Dependence

2005 • 235 citations

Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia.

1994 • 220 citations

Cyclooxygenase‐2 and 5‐lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy

2003 • 220 citations

Selenium supplementation and lung cancer incidence: an update of the nutritional prevention of cancer trial.

2002 • 217 citations

Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents

1998 • 200 citations

IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells.

1995 • 194 citations

Selenium and Lung Cancer: A Quantitative Analysis of Heterogeneity in the Current Epidemiological Literature

2004 • 179 citations

Signalling pathways involved in antiproliferative effects of IGFBP-3: a review

2001 • 168 citations

The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer

1997 • 161 citations

Multiple Clonal Abnormalities in the Bronchial Epithelium of Patients With Lung Cancer

1999 • 154 citations

Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial

1988 • 154 citations

The Natural Course of Preneoplastic Lesions in Bronchial Epithelium

2005 • 153 citations

A Randomized Phase IIb Trial of Anethole Dithiolethione in Smokers with Bronchial Dysplasia

2002 • 146 citations

Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis.

2003 • 140 citations

The role of MCM proteins in the cell cycle control of genome duplication

1996 • 139 citations

A prospective cohort study on selenium status and the risk of lung cancer.

1993 • 139 citations

COX‐2‐dependent stabilization of survivin in non‐small cell lung cancer

2003 • 135 citations

Acupuncture for smoking cessation

2002 • 131 citations

A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium

2004 • 124 citations

Improvement in Bronchial Squamous Metaplasia in Smokers Treated With Folate and Vitamin B12

1988 • 121 citations

Cyclooxygenase 2-Dependent Expression of Survivin Is Critical for Apoptosis Resistance in Non-Small Cell Lung Cancer

2004 • 121 citations

Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase

2004 • 114 citations

N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium.

2000 • 113 citations

The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in Finland

2009 • 107 citations

Expression of cyclooxygenase‐1 and cyclooxygenase‐2 in bronchial epithelium and nonsmall cell lung carcinoma

2002 • 95 citations

Analogs of Staurosporine

1998 • 92 citations

Sputum Cytopathology: Use and Potential in Monitoring the Workplace Environment by Screening for Biological Effects of Exposure

1986 • 90 citations

The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial

1992 • 86 citations

Protein Kinase C Targeting in Antineoplastic Treatment Strategies

1999 • 85 citations

Sputum cytological atypia as a predictor of incident lung cancer in a cohort of heavy smokers with airflow obstruction.

2003 • 84 citations

Total cyclooxygenase‐2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non‐small cell lung cancer patients

2005 • 76 citations

Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice

2002 • 75 citations

Rapid Insulin-Like Growth Factor (IGF)-Independent Effects of IGF Binding Protein-3 on Endothelial Cell Survival

2003 • 74 citations

SMOKING AND LUNG CANCER

1959 • 72 citations

Chemoprevention of lung cancer—from biology to clinical reality

2004 • 51 citations

Celecoxib Decreases Ki-67 Proliferative Index in Active Smokers

2006 • 50 citations

Modulation of Pulmonary Leukotriene B4 Production by Cyclooxygenase-2 Inhibitors and Lipopolysaccharide

2004 • 49 citations

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

2000 • 48 citations

Biological features of bronchial squamous dysplasia followed up by autofluorescence bronchoscopy

2004 • 44 citations

Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers.

2003 • 43 citations

Localized Deficiencies of Folic Acid in Aerodigestive Tissues

1992 • 40 citations

Inhibition of Protein Kinase C—Do We, Can We, and Should We?

1999 • 39 citations

Correlation between precancerous bronchial metaplasia and cigarette consumption, and preliminary results of retinoid treatment.

1982 • 39 citations

Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.

2003 • 38 citations

Lung cancer chemoprevention

2000 • 34 citations

Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf

2003 • 33 citations

High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia

2005 • 30 citations

The Proliferation-Specific Human Ki-67 Protein Is a Constituent of Compact Chromatin

2000 • 30 citations

Mechanisms of chemoprotection by oltipraz

1992 • 30 citations

Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity.

2001 • 27 citations

Antisense oligonucleotides to proliferating cell nuclear antigen and Ki-67 inhibit human mesangial cell proliferation.

1996 • 25 citations

Influenza Epidemic Alert

1957 • 11 citations

Chemoprevention of lung cancer

2002 • 11 citations

Excessive cigarette smoking: Statement

1957 • 9 citations

Chemoprevention for lung cancer

1998 • 2 citations