Insulin and phorbol ester stimulate phosphorylation of a 15 000 dalton membrane protein in rat diaphragm in a similar manner

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum

1989 • 449 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain

1984 • 303 citations

Insulin receptor signaling. Activation of multiple serine kinases.

1988 • 197 citations

Isolation and characterization of two distinct forms of protein kinase C.

1987 • 192 citations

The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism

1989 • 174 citations

Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes.

1987 • 171 citations

Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan.

1987 • 166 citations

Isoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardium.

1985 • 159 citations

Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation.

1986 • 158 citations

Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin.

1985 • 146 citations

Insulin Generates an Enzyme Modulator from Hepatic Plasma Membranes: Regulation of Adenosine 3′, 5′-Monophosphate Phosphodiesterase, Pyruvate Dehydrogenase, and Adenylate Cyclase*

1987 • 142 citations

Phorbol Ester Provokes Insulin-Like Effects on Glucose Transport, Amino Acid Uptake, and Pyruvate Dehydrogenase Activity in BC3H-1 Cultured Myocytes*

1985 • 130 citations

Purified protein kinase C phosphorylates a 47-kDa protein in control neutrophil cytoplasts but not in neutrophil cytoplasts from patients with the autosomal form of chronic granulomatous disease.

1988 • 127 citations

Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potein inhibitor of insulin receptor than IGF-I receptor

1988 • 121 citations

Protein Tyrosine Kinase Activity and Its Endogenous Substrates in Rat Brain: A Subcellular and Regional Survey

1988 • 108 citations

Alpha-adrenergic stimulation of sarcolemmal protein phosphorylation and slow responses in intact myocardium.

1986 • 97 citations

Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase.

1990 • 93 citations

Insulin and glucose modulate protein kinase C activity in rat adipocytes

1988 • 80 citations

Insulin stimulation of glucose uptake can be mediated by diacylglycerol in adipocytes

1988 • 79 citations

Protein phosphorylation and protein kinase activities in BC3H-1 myocytes. Differences between the effects of insulin and phorbol esters.

1986 • 78 citations

The protein kinase inhibitor staurosporine, like phorbol esters, induces the association of protein kinase C with membranes

1988 • 77 citations

Insulin increases membrane protein kinase C activity in rat diaphragm

1987 • 65 citations

Phorbol esters, but not insulin, promote depletion of cytosolic protein kinase C in rat adipocytes

1986 • 62 citations

The mechanisms of insulin action

1987 • 60 citations

Inhibition of cyclic AMP-dependent protein kinase by the polar head group of an insulin-sensitive glycophospholipid

1988 • 60 citations

Hormonal Regulation of Cyclic‐AMP‐Dependent Protein Kinase of Rat Diaphragm by Epinephrine and Insulin

1973 • 56 citations

Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose

1986 • 50 citations

Identification of a Major Defect in Insulin-Resistant Tissues of Genetically Obese (fa/fa) Rats: Impaired Protein Kinase C

1987 • 47 citations

Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice

1989 • 46 citations

Insulin and phorbol ester stimulate phosphorylation of a 40-kDa protein in adipocyte plasma membranes.

1985 • 46 citations

A stimulatory effect of insulin on phosphorylation of a peptide in sarcolemma‐enriched membrane preparation from rat skeletal muscle

1977 • 44 citations

DECREASED INSULIN RESPONSIVENESS IN FAT CELLS RENDERED PROTEIN KINASE C-DEFICIENT BY A TREATMENT WITH A PHORBOL ESTER.

1987 • 44 citations

Immunological evidence that insulin activates protein kinase C in BC3H‐1 myocytes

1989 • 41 citations

Evidence that protein kinase C is involved in regulating glucose transport in the adipocyte

1987 • 35 citations

Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes

1988 • 34 citations

Stimulation of Na⁺/H⁺Exchange by Insulin and Phorbol Ester during Differentiation of 3T3-L1 Cells. Relation to Hexose Uptake*

1988 • 32 citations

Protein-serine kinase from rat epididymal adipose tissue which phosphorylates and activates acetyl-CoA carboxylase. Possible role in insulin action

1990 • 31 citations

Phosphorylation of P1, a high mobility group‐like protein, catalyzed by casein kinase II, protein kinase C, cyclic AMP‐dependent protein kinase and calcium/calmodulin‐dependent protein kinase II

1989 • 26 citations

The effect of insulin and guanosine nucleotides on protein phosphorylations by sarcolemma membranes from skeletal muscle

1979 • 25 citations

Acridine orange, an inhibitor of protein kinase C, abolishes insulin and growth hormone stimulation of lipogenesis in rat adipocytes

1989 • 24 citations

Phosphorylation of multiple sites in a 15 000 dalton proteolipid from rat skeletal muscle sarcolemma, catalyzed by adenosine 3′,5′-monophosphate-dependent and calcium / phospholipid-dependent protein kinases

1988 • 24 citations

Protein kinase C activation patterns are determined by methodological variations. Studies of insulin action in BC3H-1 myocytes and rat adipose tissue

1990 • 23 citations

A 16 kDa protein substrate for protein kinase C and its phosphorylation upon stimulation of vasopressin receptors in rat aortic myocytes

1987 • 20 citations

Cyclic AMP‐dependent phosphorylation of a 16 kDa protein in a plasma membrane‐enriched fraction of rat aortic myocytes

1985 • 16 citations

Studies of in vivo phosphorylated proteins in BC3H‐1 myocytes suggest that protein kinase C is involved in insulin action

1989 • 16 citations

Skeletal muscle sarcolemma proteins as targets for adenosine 3′:5′-monophosphate-dependent and calcium-dependent protein kinases

1988 • 12 citations