Interleukin-6 transduction of a rat T9 glioma clone results in attenuated tumorigenicity and induces glioma immunity in Fischer F344 rats.

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Rat brain tumor models in experimental neuro-oncology: the 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas.

1998 • 354 citations

Morphological and immunochemical studies of rat glial tumors and clonal strains propagated in culture

1971 • 347 citations

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6

1988 • 292 citations

Direct evidence for the role of LGL in the inhibition of experimental tumor metastases.

1985 • 279 citations

Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.

1992 • 232 citations

Treatment of glioma by engineered interleukin 4-secreting cells.

1993 • 149 citations

The biological effects of interleukin 6

1996 • 142 citations

RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma.

1995 • 107 citations

Gene Therapy for Metastatic Brain Tumors by Vaccination with Granulocyte-Macrophage Colony-Stimulating Factor-Transduced Tumor Cells

1997 • 98 citations

Fibrosarcoma cells transduced with the IL-6 gene exhibited reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential.

1992 • 90 citations

In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors

1994 • 87 citations

On the multimeric nature of natural human interleukin-6

1991 • 69 citations

Cytokines Involved in B-Cell Differentiation and Their Sites of Action

1997 • 68 citations

Fibroblasts Genetically Engineered to Secrete Cytokines Suppress Tumor Growth and Induce Antitumor Immunity to a Murine Glioma In Vivo

1995 • 59 citations

Role of interleukin-6 in macrophage function

1996 • 54 citations

Differential retention of rhodamine 123 by avian sarcoma virus-induced glioma and normal brain tissue of the rat in vivo

1987 • 50 citations

Activation of rat alveolar macrophages to the tumoricidal state in the presence of progressively growing pulmonary metastases.

1981 • 42 citations

Immunotherapy I: Cyclosine gene transfer strategies

1996 • 42 citations

Marked cell-type-specific differences in glycosylation of human interleukin-6

1991 • 38 citations

Cloning vectors for expression of cDNA libraries in mammalian cells.

1987 • 36 citations

Cytokine gene-modified vaccines in the therapy of cancer

1996 • 33 citations

Immunostimulatory cytokines in somatic cells and gene therapy of cancer

1997 • 29 citations

Inhibitory effect of locally produced and exogenous interleukin-6 on tumor growth in vivo

1994 • 25 citations

Pathology induced by interleukin-6.

1993 • 21 citations

Cerebrovascular Effects and Tumor Kinetics after a Single Intratumoral Injection of Human Recombinant Interleukin-2 Alone or in Combination with Intravenous Chemotherapy in a Rat Model of Glioma

1992 • 21 citations

Endothelial cell-based cytokine gene delivery inhibits 9L glioma growth in vivo

1996 • 19 citations

Growth inhibition of subcutaneously transplanted human glioma by transfection-induced tumor necrosis factor-? and augmentation of the effect by ?-interferon

1994 • 16 citations

The effects of cytokine gene transfer into tumors on host cell infiltration and regression.

1996 • 13 citations

Cytokine-based gene therapy of human tumors. An overview.

1996 • 12 citations

Effects of intracarotid and intravenous infusion of human TNF and LT on established intracerebral rat gliomas.

1991 • 10 citations