Insulin Suppresses Transactivation by CAAT/Enhancer-binding Proteins β (C/EBPβ)

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Transcriptional regulation

1991 • 893 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1995 • 534 citations

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

1994 • 436 citations

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

1995 • 418 citations

Regulating Adipogenesis

1997 • 402 citations

Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ

1992 • 398 citations

An essential role for C/EBPβ in female reproduction

1997 • 387 citations

Molecular Mechanisms of Myogenic Coactivation by p300: Direct Interaction with the Activation Domain of MyoD and with the MADS Box of MEF2C

1997 • 363 citations

Physical and Functional Interaction of SMADs and p300/CBP

1998 • 351 citations

CBP-induced stimulation of c-Fos activity is abrogated by E1A.

1995 • 342 citations

Interaction and functional collaboration of p300 and C/EBPβ

1997 • 339 citations

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

2000 • 339 citations

Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1

1998 • 307 citations

Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene.

1990 • 299 citations

p300 and CBP: Partners for life and death

1999 • 299 citations

The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland

1998 • 260 citations

The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

1996 • 254 citations

Association of p300 and CBP with Simian Virus 40 Large T Antigen

1996 • 246 citations

CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity.

1995 • 230 citations

Intracellular signalling: PDK1 – a kinase at the hub of things

1999 • 221 citations

The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP).

1990 • 210 citations

A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions

1998 • 202 citations

Disruption of the c/ebpα Gene in Adult Mouse liver

1997 • 180 citations

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells

2000 • 169 citations

Phosphorylation of Rat Serine 105 or Mouse Threonine 217 in C/EBPβ Is Required for Hepatocyte Proliferation Induced by TGFα

1999 • 165 citations

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

1998 • 164 citations

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.

1991 • 161 citations

Adenovirus E1A Downregulates cJun- and JunB-Mediated Transcription by Targeting Their Coactivator p300

1996 • 156 citations

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

1995 • 148 citations

Adenovirus E1A targets key regulators of cell proliferation.

1992 • 148 citations

Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.

1994 • 144 citations

The Ability of C/EBPβ but Not C/EBPα To Synergize with an Sp1 Protein Is Specified by the Leucine Zipper and Activation Domain

1997 • 130 citations

C/EBPα: a critical regulator of genes governing integrative metabolic processes

1995 • 121 citations

Role of the Isoforms of CCAAT/Enhancer-binding Protein in the Initiation of Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription at Birth

1997 • 105 citations

Central Role for Phosphatidylinositide 3-Kinase in the Repression of Glucose-6-phosphatase Gene Transcription by Insulin

1998 • 94 citations

Hepatocyte Nuclear Factor-3 (HNF-3) Binds to the Insulin Response Sequence in the IGF Binding Protein-1 (IGFBP-1) Promoter and Enhances Promoter Function

1994 • 91 citations

Liver Gene Expression

1994 • 91 citations

Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPβ gene

1999 • 90 citations

CCAAT/Enhancer-binding Protein β Is an Accessory Factor for the Glucocorticoid Response from the cAMP Response Element in the Rat Phosphoenolpyruvate Carboxykinase Gene Promoter

1999 • 88 citations

Functional interactions between YY1 and adenovirus E1A

1995 • 84 citations

Role of CCAAT Enhancer-binding Protein β in the Thyroid Hormone and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 67 citations

Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR

2000 • 65 citations

The α-Isoform of the CCAAT/Enhancer-binding Protein Is Required for Mediating cAMP Responsiveness of the Phosphoenolpyruvate Carboxykinase Promoter in Hepatoma Cells

1996 • 60 citations

Specificity of Cyclin E-Cdk2, TFIIB, and E1A Interactions with a Common Domain of the p300 Coactivator

1999 • 56 citations

A quantitative three-dimensional model of the Drosophila optic lobes

1999 • 49 citations

A Nucleoprotein Complex containing CCAAT/Enhancer-binding Protein β Interacts with an Insulin Response Sequence in the Insulin-like Growth Factor-binding Protein-1 Gene and Contributes to Insulin-regulated Gene Expression

2001 • 45 citations

Characterization of Elements Mediating Regulation of Phosphoenolpyruvate Carboxykinase Gene Transcription by Protein Kinase A and Insulin

2000 • 20 citations