Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: Studies with receptor selective agonists

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

pA, A NEW SCALE FOR THE MEASUREMENT OF DRUG ANTAGONISM

1947 • 759 citations

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1981 • 503 citations

Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

1984 • 417 citations

pA2 and receptor differentiation: A statistical analysis of competitive antagonism

1979 • 408 citations

In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat.

1984 • 391 citations

In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord

1982 • 148 citations

In vivo studies on spinal opiate receptor systems mediating antinociception. I. Mu and delta receptor profiles in the primate.

1983 • 133 citations

III. Comparison of the antinociceptive action of Mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique

1986 • 133 citations

The increased efficacy of narcotic antagonists induced by various narcotic analgesics.

1974 • 105 citations

The μ rather than the δ subtype of opioid receptors appears to be involved in enkephalin-induced analgesia

1984 • 95 citations

The spinal cord as a site of opioid effects on gastrointestinal transit in the mouse.

1983 • 95 citations

Spinal and supraspinal opioid analgesia in the mouse: the role of subpopulations of opioid binding sites

1983 • 85 citations

Quantitative studies of the antagonism of morphine by nalorphine and naloxone.

1969 • 65 citations

The relationship between pharmacokinetics and pharmacodynamic action as applied to in vivo pA2: application to the analgesic effect of morphine.

1978 • 49 citations

Studies on the narcotic receptor in the guinea-pig ileum.

1976 • 25 citations

Partial cross tolerance to D-Ala2-D-Leu5-enkephalin after chronic spinal morphine infusion

1983 • 19 citations

Time course of antagonism of morphine antinociception by intracerebroventricularly administered naloxone in the rat

1981 • 6 citations