Cellular origin of hepatocellular carcinomas

Bone Marrow as a Potential Source of Hepatic Oval Cells

1999 • 2,439 citations

Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation

2000 • 997 citations

Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.

1956 • 670 citations

Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

1977 • 541 citations

Heterogeneity and plasticity of hepatocyte lineage cells

2001 • 399 citations

Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers.

1994 • 378 citations

Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma.

1989 • 294 citations

Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet.

1978 • 248 citations

Regression and persistence of hyperplastic hepatic nodules induced by N-2-Fluorenylacetamide and their relationship to hepatocarcinogenesis.

1971 • 221 citations

An Evaluation of Cellular Lineages in the Pathogenesis of Experimental Hepatocellular Carcinoma

1982 • 176 citations

Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver*1

1995 • 155 citations

Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine

1993 • 148 citations

Liver damage in the rat induces hepatocyte stem cells from biliary epithelial cells

1996 • 120 citations

Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.

1989 • 111 citations

Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2-fluorenylacetamide in a choline-deficient diet.

1984 • 105 citations

Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver

1998 • 99 citations

Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat.

1990 • 93 citations

In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver.

1987 • 93 citations

Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.

1991 • 87 citations

Autoradiography of “oval cells” appearing rapidly in the livers of rats fed N-2-fluorenylacetamide in a choline devoid diet

1981 • 86 citations

The stem cells of the liver ? a selective review

1992 • 85 citations

Heterogeneity of the “oval-cell” response in the hamster liver during cholangiocarcinogenesis following Clonorchis sinensis infection and dimmethylnitrosamine treatment

1997 • 80 citations

"Intestinal-type" of adenocarcinoma preferentially induced in right/caudate liver lobes of rats treated with furan.

1993 • 72 citations

Blast-like cell compartment in carcinogen-induced proliferating bile ductules.

1996 • 70 citations

Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters

1993 • 69 citations

Furan-Induced Hepatic Cholangiocarcinomas in Fischer 344 Rats

1991 • 69 citations

Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.

1985 • 61 citations

Distribution of albumin and alpha-fetoprotein mRNAs in normal, hyperplastic, and preneoplastic rat liver.

1992 • 59 citations

Characterizations of and interactions between bile ductule cells and hepatocytes in early stages of rat hepatocarcinogenesis induced by ethionine.

1991 • 54 citations

Expression of hepatocyte growth factor mRNA during oval cell activation in the rat liver

1993 • 52 citations

Liver stem cells: when the going gets tough they get going

1997 • 50 citations

The resistant hepatocyte model of carcinogenesis in the rat: the apparent independent development of oval cell proliferation and early nodules

1995 • 44 citations

Glutamine synthetase and hepatocarcinogenesis

1995 • 42 citations

Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver

1995 • 36 citations

Sequential appearance of intestinal mucosal cell types in the right and caudate liver lobes of furan-treated rats

1992 • 35 citations

An origin of presumptive preneoplastic foci and nodules from hepatocytes in chemical carcinogenesis in rat liver

1994 • 18 citations

Persistence of carcinogen induced initiated hepatocytes in liver carcinogenesis

1977 • 9 citations