Naive CD8+ but not CD4+ T cells induce maturation of dendritic cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

Dendritic cells as a tool to induce anergic and regulatory T cells

2001 • 478 citations

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

2000 • 412 citations

Duration of TCR Stimulation Determines Costimulatory Requirement of T Cells

1996 • 372 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes

1997 • 292 citations

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

Coupling and Uncoupling of Tumor Immunity and Autoimmunity

1999 • 245 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.

1996 • 201 citations

Immature Dendritic Cells Acquire Cd8+Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli

2000 • 195 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

Requirements for the Maintenance of Th1 Immunity In Vivo Following DNA Vaccination: A Potential Immunoregulatory Role for CD8+ T Cells

2000 • 150 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

1991 • 147 citations

CD8+ T Cells Mediate CD40-independent Maturation of Dendritic Cells In Vivo

1999 • 145 citations

Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance Induction

1998 • 134 citations

Swift Development of Protective Effector Functions in Naive Cd8+ T Cells against Malaria Liver Stages

2001 • 130 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

CD4⁺8⁻ help prevents rapid deletion of CD8⁺ cells after a transient response to antigen

1993 • 88 citations

Microbial and T Cell-Derived Stimuli Regulate Antigen Presentation by Dendritic Cells In Vivo

2000 • 79 citations

Generation of Tumor-associated Cytotoxic T Lymphocytes Requires Interleukin 4 from CD8+ T Cells

2001 • 71 citations

Role of MHC class I expression and CD8+ T cells in the evolution of iodine-induced thyroiditis in NOD-H2h4 and NOD mice

2000 • 42 citations

A quantitative analysis of lymphokine release from activated T cells. Evidence for a novel form of T-T collaboration in vitro.

1989 • 13 citations