Adenoviral‐mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

Genetics and biology of pancreatic ductal adenocarcinoma.

2006 • 1,520 citations

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

2001 • 1,427 citations

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

1998 • 740 citations

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.

1999 • 640 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression

2000 • 204 citations

GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity

2002 • 197 citations

Mice Lacking the p53-Effector Gene Gadd45a Develop a Lupus-Like Syndrome

2002 • 189 citations

Tumor and endothelial cell invasion of basement membranes

1998 • 184 citations

Mitogenic and antiapoptotic role of constitutive NF‐κB/Rel activity in pancreatic cancer

2003 • 172 citations

Inhibition of constitutive NF-κB activity by IκBαM suppresses tumorigenesis

2003 • 141 citations

Gadd45a and Gadd45b Protect Hematopoietic Cells from UV-induced Apoptosis via Distinct Signaling Pathways, including p38 Activation and JNK Inhibition

2006 • 123 citations

Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency.

2001 • 107 citations

Gadd45a Expression Induces Bim Dissociation from the Cytoskeleton and Translocation to Mitochondria

2005 • 102 citations

IKKβ programs to turn on the GADD45α–MKK4–JNK apoptotic cascade specifically via p50 NF-κB in arsenite response

2006 • 91 citations

Current Diagnosis and Treatment of Pancreatic Cancer in China

2005 • 89 citations

Oligomerization of Human Gadd45a Protein

2001 • 79 citations

Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin

2005 • 79 citations

Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer.

2002 • 77 citations

Induction of the p53-target gene GADD45 in HPV-positive cancer cells

1999 • 73 citations

Arsenic trioxide (As2O3) reduces the invasive and metastatic properties of cervical cancer cells in vitro and in vivo

2007 • 69 citations

Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis

2004 • 66 citations

A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile

2004 • 63 citations

Gadd45a regulates matrix metalloproteinases by suppressing ΔNp63α and β-catenin via p38 MAP kinase and APC complex activation

2003 • 60 citations

Human Topoisomerase IIα and IIβ Interact with the C-Terminal Region of p53

2000 • 60 citations

Gadd45a Interacts with Aurora-A and Inhibits Its Kinase Activity

2006 • 59 citations

Regulation of p53 target gene expression by cisplatin-induced extracellular signal-regulated kinase

2001 • 58 citations

Life and Death in Cancer GADD45 α and γ are Critical Regulators of NF- κB Mediated Escape from Programmed Cell Death

2004 • 57 citations

Reduced MTA1 Expression by RNAi Inhibits in Vitro Invasion and Migration of Esophageal Squamous Cell Carcinoma Cell Line

2005 • 51 citations

Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis

2002 • 50 citations

Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs

2006 • 41 citations

Cell Cycle-dependent Expression of Centrosomal Ninein-like Protein in Human Cells Is Regulated by the Anaphase-promoting Complex

2007 • 37 citations

Inhibition of NF-κB stabilizes gadd45α mRNA

2005 • 34 citations

GADD45α is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability

2005 • 29 citations

BRCA1 regulates caveolin-1 expression and inhibits cell invasiveness

2008 • 20 citations

Inhibition of the transcription factor nuclear factor-κB by adenoviral-mediated expression of IκBαM results in tumor cell death

1999 • 19 citations

Gadd45 mutations are uncommon in human tumour cell lines

2000 • 17 citations

Enhanced expression from the human cytomegalovirus immediate-early promoter in a non-replicating adenovirus encoded reporter gene following cellular exposure to chemical DNA damaging agents

2005 • 14 citations

Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line

2006 • 11 citations