Mitogenic and antiapoptotic role of constitutive NF‐κB/Rel activity in pancreatic cancer

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

1997 • 780 citations

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

2001 • 774 citations

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

1997 • 725 citations

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

1998 • 721 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.

1999 • 640 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

1992 • 500 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness.

1993 • 413 citations

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

1997 • 375 citations

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529

1998 • 375 citations

The Rel/NF-κB family: friend and foe

2000 • 368 citations

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

1999 • 285 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways

1997 • 239 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells.

1999 • 211 citations

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

1993 • 189 citations

Induction of NF-kappa B DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts.

1991 • 167 citations

Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes.

1997 • 164 citations

Defective IκBα in Hodgkin cell lines with constitutively active NF-κB

1998 • 129 citations

Repression of NF-κB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators

1999 • 104 citations

Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation.

2001 • 93 citations

Inhibition of nuclear factor kappa B and induction of apoptosis in T‐lymphocytes by sulfasalazine

1999 • 83 citations

Transforming growth factor α activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations☆, ☆☆

1999 • 58 citations

Plasma Membrane-Targeted Raf Kinase Activates NF-κB and Human Immunodeficiency Virus Type 1 Replication in T Lymphocytes

1998 • 53 citations