Effects of (−)-epigallocatechin-3-gallate on pancreatic beta-cell damage in streptozotocin-induced diabetic rats

Oxidative Stress and Diabetic Vascular Complications

1996 • 1,947 citations

Polyphenolic Flavanols as Scavengers of Aqueous Phase Radicals and as Chain-Breaking Antioxidants

1995 • 1,289 citations

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

1997 • 1,144 citations

Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and ?-cell damage in rat pancreas

2004 • 785 citations

Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism

2005 • 727 citations

Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability.

2002 • 708 citations

Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols

1998 • 684 citations

Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate*

2000 • 513 citations

Mechanisms of Cancer Prevention by Tea Constituents

2003 • 483 citations

Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase

2005 • 468 citations

Absorption, distribution, elimination of tea polyphenols in rats.

1997 • 452 citations

Insulin-like Biological Activity of Culinary and Medicinal Plant Aqueous Extracts in Vitro

2000 • 431 citations

Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E.

2001 • 413 citations

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases

2004 • 356 citations

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

1997 • 299 citations

Effect of black and green tea polyphenols on c-jun phosphorylation and H2O2 production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction

2000 • 270 citations

Inhibition of UVB-Induced Oxidative Stress-Mediated Phosphorylation of Mitogen-Activated Protein Kinase Signaling Pathways in Cultured Human Epidermal Keratinocytes by Green Tea Polyphenol (−)-Epigallocatechin-3-gallate

2001 • 268 citations

Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells

2005 • 212 citations

Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate

2000 • 183 citations

Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea.

1997 • 176 citations

Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice

2003 • 127 citations

Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution

2005 • 124 citations

Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic β-cell damage

2003 • 121 citations

Effects of vitamin E on oxidative stress and membrane fluidity in brain of streptozotocin-induced diabetic rats

2003 • 118 citations

Black tea increases the resistance of human plasma to lipid peroxidation in vitro, but not ex vivo

1999 • 99 citations

Catechins Induce Oxidative Damage to Cellular and Isolated DNA through the Generation of Reactive Oxygen Species

2003 • 95 citations

Insulin like activity in (−) epicatechin

1989 • 93 citations

Antibacterial activity of green tea polyphenols against Escherichia coliK 12

2000 • 89 citations

Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin

2004 • 87 citations

Protection of pancreatic beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes.

2004 • 84 citations

Generation of H2O2 during enzymic oxidation of catechin

1993 • 82 citations

Dual function of (−)-epigallocatechin gallate (EGCG) in healthy human lymphocytes

2005 • 68 citations

UV-induced NF-κB activation and expression of IL-6 is attenuated by (-)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro

2005 • 63 citations

Identification of Oxidation Products of (−)-Epigallocatechin Gallate and (−)-Epigallocatechin with H₂O₂

2000 • 59 citations

Inhibition of 1,2,4-benzenetriol-generated active oxygen species and induction of phase II enzymes by green tea polyphenols

1995 • 56 citations

Supplementation of Jurkat T Cells with Green Tea Extract Decreases Oxidative Damage Due to Iron Treatment

1999 • 53 citations

Dietary Depletion of Vitamin E and Vitamin A Inhibits Mammary Tumor Growth and Metastasis in Transgenic Mice

2004 • 42 citations

Positive modulation by Ras of interleukin-1β-mediated nitric oxide generation in insulin-secreting clonal β (HIT-T15) cells 1 1Abbreviations: IL-1β interleukin-1β; NO, nitric oxide; iNOS, induced nitric oxide synthase; IDDM, insulin-dependent diabetes mellitus; LT, lethal toxin; CNF1, cytotoxic necrotizing factor 1; PTMs, post-translational modifications; and L-NMMA: N-monomethyl-l-arginine monoacetate.

2001 • 39 citations

Oxidative stress in normal and diabetic rats.

1999 • 33 citations

Comparison of the Metabolic and Antioxidant Effects of Diltiazem and Vitamin E on Streptozotocin‐diabetic Rats

2004 • 3 citations