Methionine to Glutamine Substitutions in the C-terminal Domain of Calmodulin Impair the Activation of Three Protein Kinases

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Solvation energy in protein folding and binding

1986 • 1,853 citations

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

1992 • 1,258 citations

Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex

1992 • 1,031 citations

Backbone dynamics of calmodulin studied by nitrogen-15 relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible

1992 • 880 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

Molecular and Structural Basis of Target Recognition by Calmodulin

1995 • 752 citations

Calmodulin structure refined at 1.7 Å resolution

1992 • 709 citations

Calcium-induced conformational transition revealed by the solution structure of apo calmodulin

1995 • 672 citations

Modulation of Calmodulin Plasticity in Molecular Recognition on the Basis of X-Ray Structures

1993 • 615 citations

Calcium-induced exposure of a hydrophobic surface on calmodulin

1980 • 520 citations

Stability of alpha-helices

1987 • 356 citations

Stability of α-Helices

1995 • 339 citations

Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I

1996 • 329 citations

On the role of methionine residues in the sequence-independent recognition of nonpolar protein surfaces

1991 • 213 citations

Regulatory and structural motifs of chicken gizzard myosin light chain kinase.

1990 • 208 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

Helix‐coil stability constants for the naturally occurring amino acids in water. XXIV. Half‐cystine parameters from random poly(hydroxybutylglutamine‐<scp>CO</scp>‐S‐methylthio‐<scp>L</scp>‐cysteine)

1990 • 172 citations

Stimulation of the purified erythrocyte Ca2+-ATPase by tryptic fragments of calmodulin.

1984 • 151 citations

Intrasteric regulation of protein kinases and phosphatases

1991 • 151 citations

Interaction of calmodulin with the calmodulin binding domain of the plasma membrane calcium pump

1990 • 137 citations

Effects of Myosin Light Chain Kinase and Peptides on Ca2+ Exchange with the N- and C-terminal Ca2+ Binding Sites of Calmodulin

1996 • 129 citations

Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells.

1993 • 125 citations

Effects of pH, ionic strength, and temperature on activation by calmodulin and catalytic activity of myosin light-chain kinase

1982 • 110 citations

Interactive properties of calmodulin

1988 • 110 citations

The effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding

1989 • 96 citations

Circular dichroism studies on Ca2+-dependent protein modulator oxidized with N-chlorosuccinimide.

1978 • 91 citations

Chemical modification studies on the Ca2+-dependent protein modulator: the role of methionine residues in the activation of cyclic nucleotide phosphodiesterase.

1978 • 90 citations

Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

1992 • 77 citations

Structural Analysis of a Novel Interaction by Calmodulin: High-Affinity Binding of a Peptide in the Absence of Calcium

1995 • 76 citations

Chemical modification studies on the Ca²⁺ ion-dependent protein modulator: the role of methionine residues in the activation of cyclic nucleotide phosphodiesterase. Appendix: Circular dichroism studies on Ca²⁺ ion-dependent protein modulator oxidized with N-chlorosuccinimide

1978 • 76 citations

The effect of Met–&gt;Leu mutations on calmodulin's ability to activate cyclic nucleotide phosphodiesterase.

1994 • 68 citations

Calmodulin activation of target enzymes. Consequences of deletions in the central helix.

1990 • 65 citations

Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase.

1991 • 62 citations

Computational and site‐specific mutagenesis analyses of the asymmetric charge distribution on calmodulin

1989 • 55 citations

Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.

1990 • 46 citations

Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation.

1993 • 43 citations

Structure-based systematic isolation of conditional-lethal mutations in the single yeast calmodulin gene.

1994 • 43 citations

Direct comparison of Ca2+ requirements for calmodulin interaction with and activation of protein phosphatase.

1986 • 38 citations

Stimulation of the erythrocyte Ca²⁺‐ATPase and of bovine brain cyclic nucleotide phosphodiesterases by chemically modified calmodulin

1987 • 32 citations

The Fourth EF-Hand of Calmodulin and Its Helix−Loop−Helix Components: Impact on Calcium Binding and Enzyme Activation

1996 • 30 citations

Pseudosubstrate sequence may not be critical for autoinhibition of smooth muscle myosin light chain kinase.

1995 • 27 citations

Quantitative analysis of the free energy coupling in the system calmodulin, calcium, smooth muscle myosin light chain kinase

1987 • 25 citations

Microcalorimetric investigation of the interactions in the ternary complex calmodulin-calcium-melittin.

1987 • 23 citations

[8] Spectroscopic analyses of calmodulin and its interactions

1983 • 22 citations

Chimeras of Yeast and Chicken Calmodulin Demonstrate Differences in Activation Mechanisms of Target Enzymes

1996 • 21 citations

Calmodulin Fragments Can Not Activate Target Enzymes

1988 • 14 citations

Mutants of Smooth Muscle Myosin Light Chain Kinase at Tryptophan 800

1994 • 11 citations

[33]Synthesis and properties of CAPP1-calmodulin

1987 • 8 citations