CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Taking dendritic cells into medicine

2007 • 2,044 citations

Vaccine Adjuvants: Putting Innate Immunity to Work

2010 • 1,738 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells

2005 • 1,595 citations

BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood

2000 • 1,282 citations

Decisions About Dendritic Cells: Past, Present, and Future

2012 • 1,165 citations

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

2006 • 1,130 citations

Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice

2004 • 955 citations

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

2010 • 954 citations

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

2005 • 870 citations

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells

2010 • 755 citations

Characterization of human blood dendritic cell subsets

2002 • 739 citations

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells

2010 • 639 citations

Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1

2006 • 619 citations

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

2009 • 605 citations

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+ dendritic cells

2010 • 568 citations

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

2008 • 495 citations

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

2008 • 492 citations

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγ^nullhumanized mice

2010 • 336 citations

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets

2010 • 320 citations

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

2011 • 301 citations

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+ Dendritic Cells and a Subset of Monocytes

2008 • 297 citations

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

2009 • 280 citations

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

2011 • 273 citations

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

2009 • 272 citations

Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC

2010 • 257 citations

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

2011 • 255 citations

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

2009 • 204 citations

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

2009 • 197 citations

Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA

2005 • 192 citations

Expression of human DEC-205 (CD205) multilectin receptor on leukocytes

2006 • 154 citations

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

2011 • 129 citations

Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses

2008 • 128 citations

Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice

2012 • 117 citations

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways

2007 • 105 citations

Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display

2010 • 104 citations

Enhanced humoral and HLA‐A2‐restricted dengue virus‐specific T‐cell responses in humanized BLT NSG mice

2012 • 94 citations

Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors

2003 • 62 citations

DEC‐205/CD205⁺ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp

2007 • 54 citations

Mice with human immune system components as in vivo models for infections with human pathogens

2011 • 46 citations

Robust T-cell stimulation by Epstein-Barr virus–transformed B cells after antigen targeting to DEC-205

2013 • 42 citations

TLR9 and TLR7 agonists mediate distinct type I IFN responses in humans and nonhuman primates in vitro and in vivo

2011 • 39 citations

Development and Activation of Human Dendritic Cells In Vivo in a Xenograft Model of Human Hematopoiesis

2005 • 32 citations

Compartmentalization of allogeneic T-cell responses in the bone marrow and spleen of humanized NOD/SCID mice containing activated human resident myeloid dendritic cells

2008 • 9 citations