Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

LPS/TLR4 signal transduction pathway

2008 • 2,854 citations

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

2007 • 2,524 citations

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

2009 • 2,111 citations

Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran

2007 • 1,082 citations

Bacterial lipopolysaccharides and innate immunity

2001 • 955 citations

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

2008 • 945 citations

The Vaccine Adjuvant Monophosphoryl Lipid A as a TRIF-Biased Agonist of TLR4

2007 • 830 citations

Translating Innate Immunity into Immunological Memory: Implications for Vaccine Development

2006 • 615 citations

Adjuvants — a balance between toxicity and adjuvanticity

1993 • 544 citations

New horizons in adjuvants for vaccine development

2020 • 534 citations

Tuberculosis: Latency and Reactivation

2001 • 495 citations

Crystal Structures of Human MD-2 and Its Complex with Antiendotoxic Lipid IVa

2007 • 463 citations

Exploiting dendritic cells to improve vaccine efficacy

2002 • 320 citations

Interleukin 12p40 is required for dendritic cell migration and T cell priming afterMycobacterium tuberculosisinfection

2006 • 317 citations

Exploiting dendritic cells to improve vaccine efficacy

2002 • 260 citations

Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition

2001 • 243 citations

Enhancement of antigen-specific immunity via the TLR4 ligands MPL™ adjuvant and Ribi.529

2003 • 236 citations

Structural and functional analyses of bacterial lipopolysaccharides

2002 • 201 citations

Toll-like Receptor 2 Senses β-Cell Death and Contributes to the Initiation of Autoimmune Diabetes

2007 • 191 citations

Monophosphoryl Lipid A (MPL) Formulations for the Next Generation of Vaccines

1999 • 169 citations

Identification of Human T Cell Antigens for the Development of Vaccines against Mycobacterium tuberculosis

2008 • 162 citations

Dual Signaling of MyD88 and TRIF Is Critical for Maximal TLR4-Induced Dendritic Cell Maturation

2008 • 143 citations

A Synthetic Adjuvant to Enhance and Expand Immune Responses to Influenza Vaccines

2010 • 137 citations

Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area

2009 • 134 citations

Endotoxins: Relationships between Structure, Function, and Activity

2004 • 129 citations

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

2008 • 121 citations

The candidate tuberculosis vaccine Mtb72F/AS02A: Tolerability and immunogenicity in humans

2009 • 107 citations

Vaccinology at the beginning of the 21st century

2005 • 105 citations

Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations

2009 • 104 citations

Optimized subunit vaccine protects against experimental leishmaniasis

2009 • 100 citations

Enhanced humoral and Type 1 cellular immune responses with Fluzone® adjuvanted with a synthetic TLR4 agonist formulated in an emulsion

2009 • 95 citations

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

2009 • 89 citations

Intradermal immunization improves protective efficacy of a novel TB vaccine candidate

2009 • 88 citations

Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling

2008 • 84 citations

Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions

2008 • 81 citations

Safety and immunogenicity of a defined vaccine for the prevention of cutaneous leishmaniasis

2009 • 77 citations

Lipid A diversity and the innate host response to bacterial infection

1998 • 74 citations

A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis

2010 • 73 citations

Structural Regions of MD-2 That Determine the Agonist-Antagonist Activity of Lipid IVa

2006 • 67 citations

Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants

2010 • 63 citations

Structure of the Monophosphoryl Lipid A Moiety Obtained from the Lipopolysaccharide of Chlamydia trachomatis

1997 • 63 citations

The Development and Use of Vaccine Adjuvants

2002 • 61 citations

Vaccination with the ML0276 Antigen Reduces Local Inflammation but Not Bacterial Burden during Experimental M ycobacterium leprae Infection

2009 • 26 citations