Acute Hypoxia Enhances Spontaneous Lymph Node Metastasis in an Orthotopic Murine Model of Human Cervical Carcinoma

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

2003 • 1,276 citations

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

2000 • 1,246 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

1991 • 950 citations

Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

2002 • 939 citations

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

2003 • 864 citations

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

2002 • 658 citations

Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome

1999 • 543 citations

23 Genetic instability induced by the tumor microenvironment

1997 • 429 citations

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells.

1988 • 380 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 366 citations

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

1996 • 365 citations

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

2002 • 354 citations

Microenvironment-induced cancer metastasis

2000 • 335 citations

Reperfusion injury: Experimental evidence and clinical implications

1999 • 333 citations

The hypoxic tumour microenvironment and metastatic progression.

2003 • 326 citations

Transcriptional Response to Hypoxia in Human Tumors

2001 • 300 citations

Doxorubicin-induced apoptosis: Implications in cardiotoxicity

2002 • 296 citations

Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors.

2001 • 294 citations

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

2000 • 278 citations

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2002 • 272 citations

Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows.

1997 • 261 citations

Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.

1999 • 260 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 234 citations

Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix

1998 • 194 citations

Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis

2000 • 191 citations

Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia

1999 • 183 citations

Intercapillary Distance, Oxygen Tension and Local Recurrence in Cervix Cancer

1968 • 174 citations

Concepts of oxygen transport at the microcirculatory level

1998 • 160 citations

Prognostic factors in patients with cervix cancer treated by radiation therapy: results of a multiple regression analysis

1995 • 160 citations

Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor.

2002 • 155 citations

Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas

2003 • 143 citations

Tumor oxygenation: a matter of supply and demand.

1996 • 141 citations

Vascular endothelial growth factor-C expression and its relationship to pelvic lymph node status in invasive cervical cancer

2001 • 131 citations

Intercapillary distance measurement as an indicator of hypoxia in carcinoma of the cervix uteri

1986 • 130 citations

Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis

1999 • 130 citations

Effects of Reoxygenation on Cells From Hypoxic Regions of Solid Tumors: Anticancer Drug Sensitivity and Metastatic Potential

1990 • 119 citations

Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours

1999 • 118 citations

Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]

1995 • 118 citations

Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours

1995 • 108 citations

Hypoxia Enhances Metastatic Efficiency by Up-Regulating Mdm2 in KHT Cells and Increasing Resistance to Apoptosis

2004 • 106 citations

Intercapillary Distance, Oxygen Tension and Local Recurrence in Cervix Cancer

1968 • 103 citations

Tumor vascularity: a histological measure of angiogenesis and hypoxia.

2001 • 95 citations

High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.

1998 • 91 citations

Relationship of hypoxia to metastatic ability in rodent tumours

2001 • 88 citations

Adaptive Responses of the Endothelium to Stress

2000 • 82 citations

Tumor size and oxygenation are independent predictors of nodal diseases in patients with cervix cancer

2001 • 78 citations

Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer

1998 • 77 citations

Heterogeneity of polarographic oxygen tension measurements in cervix cancer: An evaluation of within and between tumor variability, probe position, and track depth

1997 • 75 citations

Tumor Vascularity—A Novel Prognostic Factor in Advanced Cervical Carcinoma

1995 • 74 citations

Temporal heterogeneity in oxygen tension in human melanoma xenografts

2003 • 63 citations

A model for temporal heterogeneities of tumor blood flow

2003 • 62 citations

Measuring Hypoxia in Solid Tumours&Is There a Gold Standard?

2001 • 62 citations

Orally administered pimonidazole to label hypoxic tumor cells.

2002 • 59 citations

Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode

2000 • 56 citations

Clinical Relevance of Intermittent Tumour Blood Flow

2001 • 53 citations

Hypoxia Actively Represses Transcription by Inducing Negative Cofactor 2 (Dr1/DrAP1) and Blocking Preinitiation Complex Assembly

2003 • 50 citations

Variation of vascular density within and between tumors of the uterine cervix and its predictive value for radiotherapy

1989 • 50 citations

Benign-to-Malignant B16 melanoma Progression Induced in Two Stages In Vitro by Exposure to Hypoxi

1994 • 41 citations

Metabolic and clonogenic consequences of ischaemia reperfusion insult in solid tumours

1997 • 16 citations

Detection of Microregional Fluctuations in Erythrocyte Flow Using Laser Doppler Microprobes

1996 • 7 citations