Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction

Indications for fibrinolytic therapy in suspected acute myocardial infarction : collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients

1994 • 2,250 citations

Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients

1994 • 2,186 citations

The Effects of Tissue Plasminogen Activator, Streptokinase, or Both on Coronary-Artery Patency, Ventricular Function, and Survival after Acute Myocardial Infarction

1993 • 1,861 citations

ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

1995 • 1,786 citations

Surrogate End Points in Clinical Trials: Are We Being Misled?

1996 • 1,592 citations

Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

1991 • 1,346 citations

ISIS-4 - A randomised factorial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58.050 patient with suspected acute myocardial-infarction.

1995 • 1,124 citations

Mechanism of myocardial "stunning".

1990 • 995 citations

Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilatation. III. Clinical trial

1978 • 547 citations

Science of urinary incontinence

1994 • 498 citations

Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologie coronary vasodilatation

1978 • 470 citations

Safety profile of adenosine stress perfusion imaging: Results from the adenoscan multicenter trial registry

1994 • 467 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction.

1992 • 457 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

Protective effects of adenosine in myocardial ischemia.

1992 • 410 citations

Beneficial Effects of Intracoronary Adenosine as an Adjunct to Primary Angioplasty in Acute Myocardial Infarction

2000 • 408 citations

Does reperfusion injury exist in humans?

1993 • 405 citations

Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon.

1987 • 378 citations

Selection of the optimal nonexercise stress for the evaluation of ischemic regional myocardial dysfunction and malperfusion. Comparison of dobutamine and adenosine using echocardiography and 99mTc-MIBI single photon emission computed tomography.

1993 • 368 citations

Diagnosis of coronary artery disease by controlled coronary vasodilation with adenosine and thallium-201 scintigraphy in patients unable to exercise.

1990 • 309 citations

Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs

1993 • 291 citations

Determinants of infarct size in reperfusion therapy for acute myocardial infarction.

1992 • 270 citations

Preconditioning of Human Myocardium With Adenosine During Coronary Angioplasty

1997 • 250 citations

Single photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia: Correlation with coronary arteriography, exercise thallium imaging and two-dimensional echocardiography

1990 • 240 citations

Adenosine A2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence.

1997 • 214 citations

Comparison of Adenosine, Dipyridamole, and Dobutamine in Stress Echocardiography

1992 • 206 citations

A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels.

1994 • 195 citations

Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart: a protective mechanism in early myocardial ischemia.

1987 • 191 citations

Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period.

1991 • 183 citations

Comparison of adenosine and exercise thallium-201 single-photon emission computed tomography (SPECT) myocardial perfusion imaging

1992 • 181 citations

Intravenous adenosine: Continuous infusion and low dose bolus administration for determination of coronary vasodilator reserve in patients with and without coronary artery disease

1991 • 176 citations

Intracoronary adenosine administered after reperfusion limits vascular injury after prolonged ischemia in the canine model.

1989 • 170 citations

Continuously updated 12-lead ST-segment recovery analysis for myocardial infarct artery patency assessment and its correlation with multiple simultaneous early angiographic observations

1993 • 167 citations

Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog.

1985 • 145 citations

Quantitative thallium-201 single-photon emission computed tomography during maximal pharmacologic coronary vasodilation with adenosine for assessing coronary artery disease

1991 • 120 citations

Tolerance and safety of pharmacologic coronary vasodilation with adenosine in association with thallium-201 scintigraphy in patients with suspected coronary artery disease

1991 • 117 citations

Diagnosis of ischemic heart disease with adenosine echocardiography

1991 • 96 citations

Combined tissue-type plasminogen activator and prostacyclin therapy for acute myocardial infarction

1989 • 94 citations

Intravenous Fluosol in the treatment of acute myocardial infarction. Results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. TAMI 9 Research Group.

1994 • 94 citations

Assessment of coronary artery disease using single-photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia

1991 • 93 citations

Adenosine attenuates reperfusion injury following regional myocardial ischaemia

1993 • 91 citations

Combined adenosine and lidocaine administration limits myocardial reperfusion injury.

1990 • 88 citations

Myocardium at risk and infarct size after thrombolytic therapy for acute myocardial infarction: Implications for the design of randomized trials of acute intervention

1994 • 87 citations

Beneficial Effects of RheothRx Injection in Patients Receiving Thrombolytic Therapy for Acute Myocardial Infarction

1996 • 85 citations

Residual flow to the infarct zone as a determinant of infarct size after direct angioplasty.

1993 • 84 citations

Mechanisms of myocardial “stunning”

1991 • 72 citations

Intravenous adenosine and lidocaine in patients with acute myocardial infarction

1998 • 71 citations

Effect of Adenosine on Myocardial ‘Stunning’ in the Dog

1995 • 70 citations

Combined adenosine and lidocaine administration limits myocardial reperfusion injury.

1990 • 70 citations

High-dose dipyridamole echocardiography test in coronary artery disease after heart transplantation

1993 • 68 citations

Quantitative myocardial SPECT for infarct sizing: feasibility of a multicenter trial evaluated using a cardiac phantom.

1995 • 61 citations

Comparison between dipyridamole and adenosine as pharmacologic coronary vasodilators in detection of coronary artery disease with thallium 201 imaging

1996 • 56 citations

Identification of high-risk patients with left main and three-vessel coronary artery disease by adenosine-single photon emission computed tomographic thallium imaging

1993 • 53 citations

Intravascular adenosine at reperfusion reduces infarct size and neutrophil adherence

1996 • 53 citations

Adenosine enhanced preservation of myocardial function and energetics. Possible involvement of the adenosine A1 receptor system

1993 • 51 citations

Comparison of adenosine echocardiography, with and without isometric handgrip, to exercise echocardiography in the detection of ischemia in patients with coronary artery disease1, 2

1996 • 50 citations

Intracoronary adenosine administration during reperfusion following 3 hours of ischemia: Effects on infarct size, ventricular function, and regional myocardial blood flow

1990 • 45 citations

Myocardial reperfusion injury in the canine model after 40 minutes of ischemia: Effect of intracoronary adenosine

1991 • 37 citations

Adenosine infusion to patients with ischaemic heart disease may provoke left ventricular dysfunction detected by echocardiography

1991 • 19 citations

Effect of Adenosine on Myocardial Stunning

1996 • 18 citations

Adenosine echocardiography ? an alternative to dynamic stress echocardiography

1993 • 9 citations

Adenosine echocardiography: A new pharmacologic stress test

1991 • 4 citations

Free radicals, reperfusion and myocardial infarction therapy: European Myocardial Infarction Project -- free radicals pilot study

1993 • 4 citations