Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.

Separation of leukocytes from blood and bone marrow

1968 • 2,787 citations

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

1968 • 2,659 citations

A specific method for the analysis of hydroxyproline in tissues and urine

1960 • 1,065 citations

SECRETION OF PLASMINOGEN ACTIVATOR BY STIMULATED MACROPHAGES

1974 • 719 citations

The functional relationship of the interleukins.

1980 • 660 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Secretion of a specific collagenase by stimulated macrophages.

1975 • 432 citations

The T Cell Dependence of B Cell Differentiation Induced by Pokeweed Mitogen

1976 • 409 citations

In vitro synthesis of immunoglobulin by rheumatoid synovial membrane

1968 • 324 citations

The Effect of Synovial Tissue on the Breakdown of Articular Cartilage in Organ Culture

1977 • 312 citations

Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

1980 • 282 citations

Collagenase Production by Rheumatoid Synovial Cells: Stimulation by a Human Lymphocyte Factor

1977 • 275 citations

Collagenase Production by Lymphokine-Activated Macrophages

1975 • 269 citations

A cartilage catabolic factor from synovium

1979 • 246 citations

The release of collagenase as an inactive proenzyme by bone explants in culture

1972 • 236 citations

Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors

1979 • 228 citations

Evidence that latent collagenases are enzyme-inhibitor complexes

1977 • 223 citations

Degradation of serum amyloid A protein by surface-associated enzymes of human blood monocytes.

1978 • 218 citations

Collagenases in human synovial fluid

1969 • 215 citations

RELATIONSHIP BETWEEN URINARY HYDROXYPROLINE AND GROWTH*

1962 • 196 citations

Zymogen of tadpole collagenase

1971 • 194 citations

The degradation of articular collagen by neutrophil proteinases

1977 • 189 citations

Electron microscopic studies of the cartilage‐pannus junction in rheumatoid arthritis

1975 • 157 citations

The Macrophage as a Secretory Cell

1978 • 156 citations

Lymphokines in the rheumatoid joint

1975 • 140 citations

Synthesis of collagenase and neutral proteases by articular chondrocytes: Stimulation by a macrophage-derived factor

1978 • 132 citations

Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments.

1980 • 122 citations

A tissue-culture model of cartilage breakdown in rheumatoid arthritis. Quantitative aspects of proteoglycan release

1979 • 108 citations

Electron Microscopic Studies of Lymphoid Cells in the Rheumatoid Synovial Membrane

1973 • 98 citations

Induction of the synthesis of latent collagenase and latent neutral protease in chondrocytes by a factor synthesized by activated macrophages

1980 • 90 citations

Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture.

1975 • 89 citations

Macrophage-fibroblast interactions in collagenase production and cartilage degradation

1979 • 75 citations

A NEW FACTOR THAT MAY CONTROL COLLAGEN RESORPTION

1977 • 73 citations

Macrophage Factor that Induces Neutral Protease Secretion by Normal Rabbit Chondrocytes

1980 • 63 citations

The Pathology of Rheumatoid Arthritis

1973 • 50 citations

The site of cartilage matrix degradation

1980 • 45 citations

Proteinase inhibitors in rheumatoid arthritis.

1975 • 45 citations

Activation in vitro of rheumatoid synovial collagenase from cell cultures.

1978 • 44 citations

IV. Joint erosion in rheumatoid arthritis

1974 • 37 citations

Revised nomenclature for antigen-nonspecific T cell proliferation and helper factors

1980 • 24 citations

THE MACROPHAGE AS SECRETORY CELL11Supported in part by grants (AI07012 and AI01831) from the U.S. Public Health Service, N.I.H. grant CA 08290-09 and The Rockefeller Foundation.

1975 • 17 citations

Cellular control of collagen breakdown in rheumatoid arthritis

1978 • 15 citations

Histologic assessment of lymphokine‐mediated suppression of chondrocyte glycosaminoglycan synthesis

1979 • 15 citations

Pathological Aspects of Rheumatoid Arthritis

1972 • 10 citations