Morphological and Biochemical Analyses of Amyloid Plaque Core Proteins Purified from Alzheimer Disease Brain Tissue

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1963 • 956 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Deglycosylation of glycoproteins by trifluoromethanesulfonic acid

1981 • 728 citations

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

1964 • 646 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Immune System Response in Alzheimer's Disease

1989 • 457 citations

ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY

1964 • 440 citations

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

1990 • 415 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

A rapid and sensitive method for the analysis of carbohydrate components in glycoproteins using gas-liquid chromatography

1982 • 324 citations

Complement activation in amyloid plaques in Alzheimer’s dementia

1988 • 289 citations

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.

1991 • 288 citations

Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein containing lesions of Alzheimer's disease and Down's syndrome

1990 • 245 citations

Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis.

1988 • 244 citations

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

1989 • 238 citations

Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain

1990 • 194 citations

Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease

1988 • 192 citations

β-Amyloid protein promotes neuritic branching in hippocampal cultures

1990 • 188 citations

Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.

1990 • 175 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects

1991 • 148 citations

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

1989 • 141 citations

Kunitz Protease Inhibitor-Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease

1992 • 137 citations

Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein.

1986 • 133 citations

α1-Antitrypsin and α1-antichymotrypsin are in the lesions of Alzheimerʼs disease

1992 • 128 citations

Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease

1991 • 121 citations

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

1992 • 120 citations

THE IMMUNOHISTOCHEMICAL DEMONSTRATION OF SUBSEQUENCES OF THE PRECURSOR OF THE AMYLOID A4 PROTEIN IN SENILE PLAQUES IN ALZHEIMER'S DISEASE

1989 • 119 citations

The disaccharide composition of heparins and heparan sulfates

1989 • 104 citations

β-Amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons

1991 • 103 citations

Senile plaques: staining for acetylcholinesterase and A4 protein: a comparative study in the hippocampus and entorhinal cortex

1990 • 103 citations

Amyloid β-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia

1990 • 100 citations

Sulfated glycosaminoglycans in Alzheimer's disease

1987 • 98 citations

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques.

1991 • 86 citations

Antisera to an amino-terminal peptide detect the amyloid protein precursor of alzheimer's disease and recognize senile plaques

1988 • 81 citations

AN ANALYSIS OF THE MORPHOLOGY OF SENILE PLAQUES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES USING IMMUNOCYTOCHEMICAL AND LECTIN HISTOCHEMICAL TECHNIQUES

1989 • 74 citations

Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

1989 • 67 citations

Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: Immunohistochemical and biochemical characterization

1989 • 65 citations

Distribution of the Protease Inhibitor α₁-Antichymotrypsin in Cerebral and Systemic Amyloid

1990 • 63 citations

Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties.

1991 • 54 citations

Protease nexin I immunostaining in alzheimer's disease

1989 • 50 citations

Structure of Heparan Sulfate and Dermatan Sulfate

1989 • 46 citations

Localization of calpain immunoreactivity in senile plaques and in neurones undergoing neurofibrillary degeneration in Alzheimer's disease

1991 • 45 citations

Isolation and chemical characterization of Alzheimer's disease paired helical filament cytoskeletons: differentiation from amyloid plaque core protein.

1988 • 45 citations

Tissue factor antigen in senile plaques of Alzheimer's disease.

1991 • 45 citations

NEUROPATHOLOGICAL DEFINITION OF ALZHEIMER DISEASE: MULTIVARIATE ANALYSES IN THE MORPHOMETRIC DISTINCTION BETWEEN ALZHEIMER DEMENTIA AND NORMAL AGING

1988 • 38 citations

The acid lability of the glycosidic bonds of <scp>l</scp>-iduronic acid residues in glycosaminoglycans

1980 • 38 citations

Lectin histochemistry of plaques and tangles in Alzheimer's disease

1987 • 35 citations

Alzheimer's β‐Amyloid Protein Is Covalently Modified when Dissolved in Formic Acid

1990 • 28 citations

Complement C4 Phenotypes in Dementia of the Alzheimer Type

1988 • 26 citations

Covalent modification of Alzheimer's amyloid β-peptide in formic acid solutions

1992 • 22 citations

Saccharides of senile plaques and neurofibrillary tangles in Alzheimer's disease

1988 • 18 citations

Structure and Localization of Nervous Tissue Proteoglycansa

1986 • 17 citations

Alzheimer's disease: glycolytic pretreatment dramatically enhances immunolabeling of senile plaques and cerebrovascular amyloid substance.

1989 • 16 citations

Chapter 24. Amyloidogenesis as a Therapeutic Target in Alzheimer's Disease

1991 • 15 citations

Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe

1991 • 13 citations