Effect of protein kinase C and phospholipase A₂ inhibitors on the impaired ability of human diabetic platelets to cause vasodilation

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Thromboxane Biosynthesis and Platelet Function in Type II Diabetes Mellitus

1990 • 600 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

1986 • 489 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Isolation and amino acid sequence of cyclophilin.

1986 • 294 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.

1995 • 175 citations

Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

1993 • 141 citations

Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.

1989 • 140 citations

Further studies on the specificity of diacylglycerol for protein kinase C activation

1987 • 106 citations

Aldose Reductase Inhibition Restores Endothelial Cell Function in Diabetic Rabbit Aorta

1993 • 95 citations

Response of human coronary arteries to aggregating platelets: importance of endothelium-derived relaxing factor and prostanoids.

1988 • 84 citations

Aldose reductase, glomerular metabolism, and diabetic nephropathy

1986 • 63 citations

Phosphoinositide Hydrolysis and Insulin Release From Isolated Perifused Rat Islets: Studies With Glucose

1988 • 61 citations

Role of Enhanced Arachidonate Availability Through Phospholipase A2 Pathway in Mediation of Increased Prostaglandin Synthesis by Glomeruli From Diabetic Rats

1988 • 58 citations

myo‐Inositol Metabolism in 41 A3 Neuroblastoma Cells: Effects of High Glucose and Sorbitol Levels

1987 • 50 citations

The effect of high glucose on polyol pathway activity and myoinositol metabolism in cultured human endothelial cells

1989 • 47 citations

Platelets from patients with diabetes mellitus have impaired ability to mediate vasodilation

1996 • 46 citations

Aldose reductase and myo-inositol in endothelial cell dysfunction caused by elevated glucose.

1992 • 33 citations

Role of enhanced arachidonate availability through phospholipase A2 pathway in mediation of increased prostaglandin synthesis by glomeruli from diabetic rats

1988 • 21 citations

Phosphoinositide hydrolysis and insulin release from isolated perifused rat islets. Studies with glucose

1988 • 18 citations

Changes in sorbitol,myo-inositol and lipid inositol in dorsal root and sympathetic ganglia from streptozotocin-diabetic rats

1986 • 18 citations

Diabetic human platelets release a substance that inhibits platelet-mediated vasodilation

1997 • 13 citations

1901-121 Profound Inhibition of Arterial Thrombosis by a Novel Nitric Oxide Donor

1995 • 4 citations