Natural Killer Cells and Cytotoxic T Cells Induce DNA Fragmentation in Both Human and Murine Target Cells in Vitro

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

1974 • 832 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Death and the cell

1986 • 616 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.

1982 • 500 citations

Mechanism of Cytotoxicity by Natural Killer (NK) Cells

1986 • 272 citations

Homology of perforin to the ninth component of complement (C9)

1988 • 268 citations

Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

1975 • 217 citations

Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells

1987 • 201 citations

Natural cell‐mediated cytotoxicity in mice against non‐lymphoid tumor cells and some normal cells

1977 • 174 citations

Cytotoxic T cells specific for influenza virus-infected target cells.

1977 • 114 citations

Cell-mediated killing: A common mechanism?

1986 • 114 citations

Mechanisms of immune lysis. III. Characterization of the nature and kinetics of the cytotoxic T lymphocyte-induced nuclear lesion in the target.

1982 • 113 citations

Identification, isolation, and characterization of a novel cytotoxin in murine cytolytic lymphocytes

1987 • 113 citations

Cellular and Humoral Mechanisms of Cytotoxicity: Structural and Functional Analogies

1987 • 111 citations

Differences in target cell DNA fragmentation induced by mouse cytotoxic T lymphocytes and natural killer cells.

1986 • 102 citations

THE MECHANISM OF LYMPHOCYTE‐MEDIATED CYTOTOXICITY

1981 • 84 citations

Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro.

1988 • 79 citations

Natural killer activity: the definition of a function rather than a cell type

1987 • 58 citations

DNA of human Raji target cells is damaged upon lymphocyte-mediated lysis.

1986 • 55 citations

Cytolytic T-cell melodrama

1987 • 51 citations

Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes.

1988 • 48 citations

Perforin — a primary pr auxiliary lytic mechanism?

1988 • 41 citations

Lack of lymphocyte-induced DNA fragmentation in human targets during lysis represents a species-specific difference between human and murine cells.

1985 • 19 citations

Alloreactive Cytotoxic T Lymphocytes Lyse Syngeneic Influenza-Infected Tumour Cell Targets

1984 • 12 citations

Artificial T cell:B cell conjugation. A unique approach to analyze weak cell-cell interactions.

1988 • 3 citations