Perforin — a primary pr auxiliary lytic mechanism?

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

Plasma cell immunoglobulin secretion. Arrest is accompanied by alterations the golgi complex

1977 • 404 citations

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.

1984 • 337 citations

Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction

1977 • 258 citations

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes.

1983 • 229 citations

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

1987 • 196 citations

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

1987 • 174 citations

Cell-mediated killing: A common mechanism?

1986 • 114 citations

Identification, isolation, and characterization of a novel cytotoxin in murine cytolytic lymphocytes

1987 • 113 citations

The lethal hit stage of mouse T and non‐T cell‐mediated cytolysis: differences in cation requirements and characterization of an analytical “cation pulse” method

1976 • 93 citations

Membrane-mediated cytotoxicity

1986 • 73 citations

T-lymphocyte-mediated cytolysis as an excitatory process of the target

1985 • 71 citations

Identification of granzyme A isolated from cytotoxic T‐lymphocyte‐granules as one of the proteases encoded by CTL‐specific genes

1986 • 68 citations

A calcium- and perforin-independent pathway of killing mediated by murine cytolytic lymphocytes.

1987 • 64 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. VI. A reappraisal of the requirement for protein synthesis during T cell-mediated lysis.

1976 • 43 citations

Studies on the Mechanism of Lymphocyte-Mediated Cytolysis

1976 • 27 citations

The Role of Cytoplasmic Granules in Cytotoxicity by Large Granular Lymphocytes and Cytotoxic T Lymphocytes

1985 • 26 citations

Granzyme A secretion by normal activated Lyt‐2⁺ and L3T4⁺ T cells in response to antigenic stimulation

1987 • 19 citations

Cytolytic T-Cell Granules: Biochemimcal Properties and Functional Specificity

1985 • 13 citations