Stable DNA transformation in the obligate intracellular parasite Toxoplasma gondii by complementation of tryptophan auxotrophy.

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

Toxoplasmic Encephalitis in AIDS

1992 • 1,293 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Replacement of chromosome segments with altered DNA sequences constructed in vitro.

1979 • 779 citations

Virulent strains of Toxoplasma gondii comprise a single clonal lineage

1992 • 779 citations

Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii.

1988 • 451 citations

Transient Transfection and Expression in the Obligate Intracellular Parasite Toxoplasma gondii

1993 • 353 citations

Gene Replacement in Toxoplasma gondii with Chloramphenicol Acetyltransferase as Selectable Marker

1993 • 283 citations

Gene replacement in parasitic protozoa

1990 • 238 citations

Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes.

1990 • 222 citations

Specific Labeling of Intracellular Toxoplasma gondii with Uracil*

1977 • 209 citations

Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages

1989 • 201 citations

Two dominant-acting selectable markers for gene transfer studies in mammalian cells.

1988 • 184 citations

Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei

1990 • 177 citations

Stable expression of the bacterial neor gene in Leishmania enriettii

1990 • 159 citations

Nucleotide sequence of the trpB gene in Escherichia coli and Salmonella typhimurium

1980 • 151 citations

IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth.

1993 • 146 citations

Homologous Recombination and Stable Transfection in the Parasitic Protozoan Trypanosoma brucei

1990 • 135 citations

Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii.

1992 • 134 citations

Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii

1994 • 94 citations

Stable integrative transformation of Trypanosoma brucei that occurs exclusively by homologous recombination.

1991 • 94 citations

Toxoplasma gondii: Genetic recombination between drug resistant mutants

1980 • 91 citations

Molecular characterization of a dense granule antigen (Gra 2) associated with the network of the parasitophorous vacuole in Toxoplasma gondii

1993 • 77 citations

Interactions between Toxoplasma gondii and its mammalian host cells

1993 • 50 citations

Polypeptide antibody binding mechanism: Conformational adaptation investigated by equilibrium and kinetic analysis

1989 • 48 citations

Quantitative Studies of the Mutagenesis of Toxoplasma gondii

1979 • 38 citations