Caspase-7 Gene Disruption Reveals an Involvement of the Enzyme during the Early Stages of Apoptosis

The biochemistry of apoptosis

2000 • 7,314 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Caspases: Enemies Within

1998 • 6,923 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis

2001 • 1,079 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

Caspase-9 and APAF-1 form an active holoenzyme

1999 • 566 citations

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

2002 • 564 citations

Increased ratio of targeted to random integration after transfection of chicken B cell lines

1991 • 534 citations

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis

1996 • 484 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Serial killers: ordering caspase activation events in apoptosis

1999 • 468 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis

1999 • 431 citations

Mitochondrial endonuclease G is important for apoptosis in C. elegans

2001 • 416 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Phosphatidylserine Externalization during CD95-induced Apoptosis of Cells and Cytoplasts Requires ICE/CED-3 Protease Activity

1996 • 386 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

Caspases: their intracellular localization and translocation during apoptosis

1999 • 358 citations

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

2000 • 311 citations

Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

2002 • 301 citations

Caspase knockouts: matters of life and death

1999 • 279 citations

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

2002 • 254 citations

Regulation of Phospholipid Scramblase Activity during Apoptosis and Cell Activation by Protein Kinase Cδ

2000 • 242 citations

Structural basis for the activation of human procaspase-7

2001 • 213 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45

1998 • 194 citations

Caspases: cellular demolition experts

2001 • 182 citations

Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II.

1990 • 181 citations

Implication of calpain in caspase activation during B cell clonal deletion

1999 • 178 citations

Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis

2000 • 125 citations

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

2002 • 120 citations

Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli

1999 • 120 citations

CAD/DFF40 Nuclease Is Dispensable for High Molecular Weight DNA Cleavage and Stage I Chromatin Condensation in Apoptosis

2001 • 106 citations

Caspase‐3 is not essential for DNA fragmentation in MCF‐7 cells during apoptosis induced by the pyrrolo‐1,5‐benzoxazepine, PBOX‐6

2002 • 105 citations

Caspase-Independent Phosphatidylserine Exposure During Apoptosis of Primary T Lymphocytes

2002 • 90 citations

Comparison of Paclitaxel-, 5-Fluoro-2′-deoxyuridine-, and Epidermal Growth Factor (EGF)-induced Apoptosis

1999 • 88 citations

Lack of Correlation between Caspase Activation and Caspase Activity Assays in Paclitaxel-treated MCF-7 Breast Cancer Cells

2002 • 72 citations

Apoptotic Cleavage of Cytoplasmic Dynein Intermediate Chain and P150GluedStops Dynein-Dependent Membrane Motility

2001 • 53 citations

Caspase activation by BCR cross‐linking in immature B cells: differential effects on growth arrest and apoptosis

1999 • 52 citations

Caspase-3-like activity determines the type of cell death following ionizing radiation in MOLT-4 human leukaemia cells

2000 • 41 citations

Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C α activity

2001 • 41 citations

Involvement of Polyamines in B Cell Receptor–Mediated Apoptosis: Spermine Functions as a Negative Modulator

2001 • 41 citations