Synergistic interaction between insulin-like growth factors-I and -II in central regulation of pulsatile growth hormone secretion.

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary

1981 • 829 citations

Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat

1976 • 743 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

The Effects of Short‐Term Application of a Combination of Platelet‐Derived and Insulin‐Like Growth Factors on Periodontal Wound Healing

1991 • 472 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

1983 • 354 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Insulin-Like Growth Factor I (IGF-I)-Binding Protein Complex Is a Better Mitogen than Free IGF-I*

1989 • 318 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

Human Growth Hormone and Somatomedin C Suppress the Spontaneous Release of Growth Hormone in Unanesthetized Rats*

1983 • 277 citations

Insulin-Like Growth Factor I Action on Rat Anterior Pituitary Cells: Suppression of Growth Hormone Secretion and Messenger Ribonucleic Acid Levels*

1986 • 265 citations

Receptors for Insulin-like Growth Factors I and II: Autoradiographic Localization in Rat Brain and Comparison to Receptors for Insulin*

1988 • 252 citations

Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins

1980 • 250 citations

Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.

1985 • 205 citations

Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

1984 • 199 citations

Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells.

1984 • 168 citations

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

1986 • 165 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

1982 • 158 citations

The Growth Hormone (GH)-Releasing Hormone (GHRH)- GH-Somatomedin Axis: Evidence for Rapid Inhibition of GHRH-Elicited GH Release by Insulin-Like Growth Factors I and II*

1987 • 138 citations

Insulinlike growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells.

1987 • 138 citations

Localization of Type I Insulin-Like Growth Factor Receptor Messenger RNA in the Adult Rat Brain byin SituHybridization

1991 • 122 citations

Synergistic Effects of Epidermal Growth Factor (EGF) and Insulin-Like Growth Factor I/Somatomedin C (IGF-I) on Keratinocyte Proliferation May Be Mediated by IGF-I Transmodulation of the EGF Receptor

1991 • 117 citations

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

1987 • 107 citations

Histochemical localization of IGF-I and IGF-II mRNA in the rat between birth and adulthood

1988 • 102 citations

Regulation of Growth Hormone Release from Cultured Human Pituitar Adenomas by Somatomedins and Insulin*

1985 • 99 citations

The Fetal Rat Binding Protein for Insulin-Like Growth Factors is Expressed in the Choroid Plexus and Cerebrospinal Fluid of Adult Rats

1989 • 94 citations

Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.

1989 • 76 citations

In vitro release of growth hormone-releasing factor from rat hypothalamus: effect of insulin-like growth factor-1

1986 • 71 citations

Insulin-Like Growth Factor-I Action on Growth Hormone Secretion and Messenger Ribonucleic Acid Levels: Interaction with Somatostatin*

1989 • 62 citations

Somatomedin levels in cerebrospinal fluid from adults with pituitary disorders

1984 • 58 citations

Insulin-Like Growth Factor-I Action on Hypothyroid Rat Pituitary Cells: Suppression of Triiodothyronine- Induced Growth Hormone Secretion and Messenger Ribonucleic Acid Levels*

1986 • 53 citations

Contrasting Modulation by Transforming Growth Factor-β-1 of Insulin-Like Growth Factor-I Production in Osteoblasts and Chondrocytes

1990 • 41 citations

Type I IGF receptors of Leydig cells are upregulated by human chorionic gonadotropin

1987 • 20 citations

Centrally Administered Insulin-Like Growth Factor II Fails to Alter Pulsatile Growth Hormone Secretion or Food Intake

1992 • 18 citations

The effects of insulin-like growth factor-I (IGF-I), IGF-II and des(1–3)IGF-I, a potent IGF analogue, on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells

1991 • 17 citations

Insulin-like growth factor inhibition of growth hormone secretion

1986 • 11 citations

The Growth Hormone

1932 • 3 citations