Current status of non-digitalis positive inotropic drugs

Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

1991 • 2,186 citations

A Comparison of Oral Milrinone, Digoxin, and Their Combination in the Treatment of Patients with Chronic Heart Failure

1989 • 561 citations

Hemodynamic Assessment of Amrinone

1978 • 390 citations

Evaluation of a New Bipyridine Inotropic Agent — Milrinone — in Patients with Severe Congestive Heart Failure

1983 • 340 citations

Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo. Enoximone Multicenter Trial Group.

1990 • 328 citations

Low-dose dobutamine in patients with acute myocardial infarction identifies viable but not contractile myocardium and predicts the magnitude of improvement in wall motion abnormalities in response to coronary revascularization

1991 • 269 citations

Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure. Dose-response relationships and comparison to nitroprusside.

1985 • 258 citations

Amrinone: a new non-glycosidic, non-adrenergic cardiotonic agent effective in the treatment of intractable myocardial failure in man.

1979 • 215 citations

Improvement in indexes of diastolic performance in patients with congestive heart failure treated with milrinone.

1984 • 207 citations

Long-term oral administration of amrinone for congestive heart failure: lack of efficacy in a multicenter controlled trial.

1985 • 204 citations

Effects of milrinone on coronary hemodynamics and myocardial energetics in patients with congestive heart failure.

1985 • 184 citations

Systemic and coronary effects of intravenous milrinone and dobutamine in congestive heart failure

1986 • 158 citations

Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure.

1983 • 147 citations

Pharmacology and inotropic potential of forskolin in the human heart.

1984 • 131 citations

Hemodynamic effects of intravenous digoxin in patients with severe heart failure initially treated with diuretics and vasodilators

1987 • 130 citations

DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties

1985 • 119 citations

Oral amrinone for the treatment of chronic congestive heart failure: Results of a multicenter randomized double-blind and placebo-controlled withdrawal study

1984 • 115 citations

Efficacy and safety of sustained (48 hour) intravenous infusions of milrinone in patients with severe congestive heart failure: A multicenter study

1987 • 114 citations

Beneficial Hemodynamic Effects of Oral Levodopa in Heart Failure

1984 • 111 citations

Sustained beneficial effects of oral amrinone on cardiac and renal function in patients with severe congestive heart failure

1980 • 106 citations

Amrinone and exercise performance in patients with chronic heart failure

1981 • 103 citations

Differential effects of milrinone and dobutamine on right ventricular preload, afterload and systolic performance in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

1987 • 99 citations

Milrinone in congestive heart failure: Acute and chronic hemodynamic and clinical evaluation

1985 • 98 citations

Cardiovascular pharmacology of dopexamine in low output congestive heart failure

1988 • 97 citations

Intravenous and oral MDL 17043 (A new inotrope-vasodilator agent) in congestive heart failure: Hemodynamic and clinical evaluation in 38 patients

1984 • 95 citations

Haemodynamic effects of intravenous amrinone in patients with impaired left ventricular function.

1983 • 94 citations

Comparison of intravenous milrinone and dobutamine for congestive heart failure secondary to either ischemic or dilated cardiomyopathy

1987 • 90 citations

Long-term amrinone therapy in patients with severe heart failure

1982 • 90 citations

Acute substantial benefit of inotropic therapy with amrinone on exercise hemodynamics and metabolism in severe congestive heart failure.

1981 • 90 citations

Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart.

1987 • 89 citations

Oral amrinone in refractory congestive heart failure

1980 • 86 citations

Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels.

1986 • 85 citations

Identification of the direct vasodilator effect of milrinone with an isolated limb preparation in patients with chronic congestive heart failure.

1986 • 84 citations

Acute haemodynamic and metabolic effects of dopexamine, a new dopaminergic receptor agonist, in patients with chronic heart failure.

1985 • 82 citations

Inotropic therapy for refractory congestive heart failure with oral fenoximone (MDL-17,043): poor long-term results despite early hemodynamic and clinical improvement.

1985 • 81 citations

Side effects of amrinone therapy.

1983 • 81 citations

Positive inotropic and vasodilator effects of MDL 17,043 in patients with reduced left ventricular performance

1984 • 75 citations

Myocardial metabolic and hemodynamic effects of intravenous MDL-17,043, a new cardiotonic drug, in patients with chronic severe heart failure

1984 • 74 citations

Pharmacokinetics and pharmacodynamics of milrinone in chronic congestive heart failure

1985 • 71 citations

Influence of positive inotropic therapy on pulsatile hydraulic load and ventricular-vascular coupling in congestive heart failure

1990 • 68 citations

Inotropic and vasodilator effects of amrinone on isolated human tissue

1984 • 66 citations

Myocardial energetics and clinical response to the cardiotonic agent MDL 17043 in advanced heart failure

1984 • 65 citations

Relative contribution of inotropic and vasodilator effects to amrinone-induced hemodynamic improvement in congestive heart failure

1986 • 65 citations

Comparison of the effects of amrinone and sodium nitroprusside on haemodynamics, contractility, and myocardial metabolism in patients with cardiac failure due to coronary artery disease and dilated cardiomyopathy.

1984 • 64 citations

Amrinone therapy for congestive heart failure in outpatients with idiopathic dilated cardiomyopathy

1983 • 59 citations

MDL 17,043 therapy in severe congestive heart failure: Characterization of the early and late hemodynamic, pharmacokinetic, hormonal and clinical response

1985 • 58 citations

Usefulness of dopexamine hydrochloride versus dobutamine in chronic congestive heart failure and effects on hemodynamics and urine output

1990 • 55 citations

Assessment of the inotropic and vasodilator effects of amrinone versus isoproterenol

1984 • 54 citations

Inotropic effect of enoximone in patients with severe heart failure: Demonstration by left ventricular end-systolic pressure-volume analysis

1987 • 52 citations

A placebo-controlled, randomized, double-blind study of OPC-8212 in patients with mild chronic heart failure

1990 • 51 citations

Cardiovascular Effects of Forskolin (HL 362) in Patients with Idiopathic Congestive Cardiomyopathy—A Comparative Study with Dobutamine and Sodium Nitroprusside

1990 • 51 citations

The Dopamine Congener, Ibopamine, in Congestive Heart Failure

1984 • 48 citations

Effects of Levodopa on Systolic Preejection Period, Blood Pressure, and Heart Rate during Acute and Chronic Treatment of Parkinson's Disease

1972 • 48 citations

MDL 17,043: Short- and long-term cardiopulmonary and clinical effects in patients with heart failure

1985 • 48 citations

Dynamics of functional mitral regurgitation during dobutamine therapy in patients with severe congestive heart failure: A Doppler echocardiographic study

1989 • 46 citations

Sustained hemodynamic improvement during long-term therapy with levodopa in heart failure: Role of plasma catecholamines

1987 • 45 citations

Acute dose range study of milrinone in congestive heart failure

1985 • 44 citations

Beneficial Haemodynamic Effects of Intravenous Dopexamine in Patients with Low-Output Heart Failure

1987 • 40 citations

Evidence for possible increase of sodium channel open time and involvement of Na/Ca exchange by a new positive inotropic drug: OPC-8212

1985 • 39 citations

Pimobendane (UD‐CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross‐over and double‐blind study with two different doses.

1988 • 38 citations

Comparative hemodynamic effects of intravenous dobutamine and MDL-17,043, a new cardioactive drug, in severe congestive heart failure

1985 • 38 citations

Short-term haemodynamic effects of dopexamine in patients with chronic congestive heart failure

1986 • 36 citations

Acute hemodynamic effect of oral MDL 17,043 in severe congestive heart failure

1984 • 36 citations

Acute hemodynamic effects of a new inotropic agent (OPC-8212) in patients with congestive heart failure

1987 • 34 citations

Evaluation of a new inotropic agent, OPC-8212, in patients with dilated cardiomyopathy and heart failure

1988 • 32 citations

Pimobendane (UD-CG115 BS) in Chronic Congestive Heart Failure

1988 • 31 citations

Comparative acute hemodynamic effects of intravenous sodium nitroprusside and MDL-17,043, a new inotropic drug with vasodilator effects, in refractory congestive heart failure

1985 • 31 citations

Dobutamine increases cardiac output of the total artificial heart. Implications for vascular contribution of inotropic agents to augmented ventricular function.

1991 • 30 citations

Hemodynamic effects of pimobendan given orally in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

1989 • 29 citations

OPC-8212 in the treatment of congestive heart failure: Results of a pilot study

1988 • 29 citations

Amrinone in severe congestive heart failure: another look at an intriguing new cardioactive drug.

1984 • 28 citations

Comparative hemodynamic and hormonal response of enoximone and dobutamine in severe congestive heart failure

1986 • 28 citations

Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure

1987 • 27 citations

Persistent hemodynamic effects without long-term clinical benefits in response to oral piroximone (MDL 19,205) in patients with congestive heart failure.

1986 • 26 citations

Effects of a new cardiotonic agent, MDL-17,043, on myocardial contractility and left ventricular performance in congestive heart failure

1985 • 26 citations

Influence of UDCG-115 on hemodynamics and myocardial energetics in patients with idiopathic dilated cardiomyopathy

1989 • 25 citations

Hemodynamic And Clinical Response To Three-Day Infusion Of Sulmazol (Ar-L 115 Bs) In Severe Congestive Heart Failure

1983 • 24 citations

DPI 201-106 for severe congestive heart failure

1987 • 23 citations

Mechanism of the Vasodilator Effects of the Cardiotonic Agent DPI 201-106

1985 • 22 citations

Acute effects of ibopamine hydrochloride on hemodynamics, plasma catecholamine levels, renin activity, aldosterone, metabolism and blood gas in patients with severe congestive heart failure.

1986 • 22 citations

Central and regional hemodynamic effects of oral enoximone in congestive heart failure: A double-blind, placebo-controlled study

1988 • 21 citations

Ibopamine in very severe congestive heart failure: Pilot haemodynamic invasive assessment

1983 • 21 citations

Disparity between improvement in left ventricular function and changes in clinical status and exercise capacity during chronic enoximone therapy

1989 • 21 citations

Acute hemodynamic response to low dose enoximone (MDL 17,043): An oral dose-range study

1987 • 20 citations

Piroximone (MDL 19,205) in the treatment of unstable and stable chronic cardiac failure

1987 • 20 citations

Systemic and coronary hemodynamic and neurohumoral effects of levodopa in chronic congestive heart failure

1988 • 19 citations

The Long-Term Efficacy of Ibopamine in Treating Patients with Severe Heart Failure

1989 • 17 citations

Long-Term Therapy of Chronic Congestive Heart Failure with Ibopamine

1989 • 17 citations

Central and renal hemodynamic effects of a new agonist at peripheral dopamine- and beta-2 adrenoreceptors (dopexamine) in patients with heart failure

1989 • 16 citations

Adverse effects of long-term amrinone administration in congestive heart failure

1983 • 16 citations

Treatment of Mild Chronic Congestive Heart Failure with Ibopamine, Hydrochlorothiazide, Ibopamine plus Hydrochlorothiazide or Placebo

1990 • 15 citations

The Hemodynamic Effects of Ibopamine, a Dopamine Congener, in Patients with Congestive Heart Failure

1986 • 14 citations

Lack of tolerance development during chronic ibopamine administration to patients with congestive heart failure

1988 • 14 citations

Dopaminergic drugs in the management of chronic heart failure

1991 • 13 citations

Noninvasive assessment of diastolic and systolic properties of ibopamine in patients with congestive heart failure

1989 • 12 citations

Augmentation of diastolic function with phosphodiesterase inhibition in congestive heart failure.

1989 • 12 citations

Oral Enoximone Pharmacokinetics in Patients with Congestive Heart Failure

1987 • 10 citations

Hemodynamic evaluation during exercise test after acute and chronic ibopamine treatment in patients with congestive heart failure.

1986 • 9 citations

Ibopamine in the Treatment of Mild Chronic Heart Failure in Elderly Patients

1990 • 6 citations

The combination of antianginal drugs: Effects and indications

1988 • 5 citations

Six-Month Treatment of Congestive Heart Failure with Ibopamine: A Double-Blind Randomized, Placebo-Controlled Multicenter Trial

1991 • 4 citations

Comparison of digoxin and dobutamine in patients with severe dilatative cardiomyopathy.

1989 • 3 citations

Acute hemodynamic effects of adibendan, a new phosphodiesterase inhibitor, for severe congestive heart failure

1989 • 3 citations

Extracardial Effects of Oral Ibopamine versus Furosemide in Patients with Mild or Moderate Heart Failure

1990 • 3 citations

Deleted Work

1955 • 0 citations