Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1996 • 444 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

The discovery of potent cRaf1 kinase inhibitors

2000 • 202 citations

Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach

2001 • 84 citations

Protein kinase inhibitors: emerging pharmacophores 1997 - 2000

2001 • 71 citations

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors

2000 • 52 citations

Discovery of a new class of p38 kinase inhibitors

2000 • 47 citations

p38 Kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas

2001 • 44 citations

The Role of Raf Kinases in Development and Growth of Tumors

1997 • 34 citations

Raf kinase inhibitors

1998 • 1 citations