Presence of a DNA-4236 bp deletion and 8-hydroxy-deoxyguanosine in mouse cardiac mitochondrial DNA during aging

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Sequence and gene organization of mouse mitochondrial DNA

1981 • 1,712 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy.

1989 • 504 citations

Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat

1969 • 382 citations

Oxidative damage to mitochondrial DNA and its relationship to ageing

1995 • 350 citations

Oxidative Phosphorylation Diseases

1990 • 338 citations

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1992 • 284 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Mitochondrial DNA mutations in human degenerative diseases and aging

1995 • 224 citations

Do mitochondrial DNA fragments promote cancer and aging?

1988 • 224 citations

Multiple mitochondrial DNA deletions in an elderly human individual

1992 • 214 citations

Deleterious mitochondrial DNA mutations accumulate in aging human tissues

1992 • 212 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice

1995 • 159 citations

Occurrence of a Particular Base Substitution (3243 A to G) in Mitochondrial DNA of Tissues of Ageing Humans

1993 • 134 citations

Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death

1995 • 124 citations

A Deletion of Mitochondrial DNA in Murine Doxorubicin-Induced Cardiotoxicity

1993 • 104 citations

Whole Mitochondrial Genome Amplification Reveals Basal Level Multiple Deletions in mtDNA of Patients with Dilated Cardiomyopathy

1995 • 77 citations

Mapping of heteroplasmic mitochondrial DNA deletions in Kearns-Sayre syndrome

1989 • 65 citations

Multiple Deletions in Mitochondrial DNA Are Present in Senescent Mouse Brain

1994 • 56 citations

The universality of bioenergetic disease and amelioration with redox therapy

1995 • 48 citations

[14] The segmented paper method: DNA synthesis and mutagenesis by rapid microscale “shotgun gene synthesis”

1987 • 9 citations

Schorstein Lecture ON THE CHRONIC INFLAMMATORY DISEASES OF THE SPLEEN.

1921 • 1 citations