Cholinergic Stimulation of Inositol Phosphate Formation in Bovine Adrenal Chromaffin Cells: Distinct Nicotinic and Muscarinic Mechanisms

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

The dependence of contraction and relaxation of muscle fibres from the crab Maia squinado on the internal concentration of free calcium ions

1964 • 1,034 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.

1983 • 394 citations

Catecholamine secretion from digitonin-treated adrenal medullary chromaffin cells.

1983 • 338 citations

The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cells

1983 • 269 citations

Calcium-evoked secretion from digitonin-permeabilized adrenal medullary chromaffin cells.

1983 • 247 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain

1984 • 241 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase.

1984 • 219 citations

Relationship Between Ca²⁺ Uptake and Catecholamine Secretion in Primary Dissociated Cultures of Adrenal Medulla

1982 • 203 citations

Muscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine Secretion

1981 • 193 citations

Calcium Uptake and Catecholamine Secretion by Cultured Bovine Adrenal Medulla Cells

1982 • 180 citations

Bovine adrenal chromaffin cells: high-yield purification and viability in suspension culture

1983 • 178 citations

Evoked transient intracellular free Ca ²⁺ changes and secretion in isolated bovine adrenal medullary cells

1983 • 177 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the cAMP-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 177 citations

Effects of phorbol ester on catecholamine secretion and protein phosphorylation in adrenal medullary cell cultures.

1985 • 170 citations

Pharmacological dissection of receptor-associated and voltage-sensitive ionic channels involved in catecholamine release

1983 • 155 citations

Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.

1984 • 152 citations

METABOLISM OF PHOSPHATIDYL INOSITOL AND OTHER LIPIDS IN ACTIVE NEURONES OF SYMPATHETIC GANGLIA AND OTHER PERIPHERAL NERVOUS TISSUES. THE SITE OF THE INOSITIDE EFFECT*

1965 • 142 citations

THE ACETYLCHOLINE RECEPTOR OF THE ADRENAL MEDULLA¹

1977 • 134 citations

Effects of phorbol esters, diglyceride, and cholinergic agonists on the subcellular distribution of protein kinase C in intact or digitonin-permeabilized adrenal chromaffin cells.

1986 • 134 citations

Effects of secretagogues on [32P]phosphatidylinositol 4,5-bisphosphate metabolism in the exocrine pancreas

1983 • 128 citations

Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities.

1985 • 124 citations

Calcium mobilization and catecholamine secretion in adrenal chromaffin cells. A Quin-2 fluorescence study.

1986 • 112 citations

Muscarinic receptors on bovine chromaffin cells mediate a rise in cytosolic calcium that is independent of extracellular calcium.

1985 • 109 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the acetylcholine-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 106 citations

Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization

1985 • 96 citations

Muscarinic receptor enhancement of nicotine-induced catecholamine secretion may be mediated by phosphoinositide metabolism in bovine adrenal chromaffin cells.

1986 • 91 citations

Protein phosphorylation and secretion in digitonin-permeabilized adrenal chromaffin cells. Effects of micromolar Ca2+, phorbol esters, and diacylglycerol.

1986 • 85 citations

Inositol Trisphosphate Mobilizes Intracellular Calcium in Permeabilized Adrenal Chromaffin Cells

1986 • 85 citations

Characterization of protein kinase C and its role in catecholamine secretion from bovine adrenal-medullary cells

1985 • 80 citations

Calcium ion requirement for acetylcholine-stimulated breakdown of triphosphoinositide in rabbit iris smooth muscle.

1978 • 73 citations

THE DIFFERENT EFFECTS OF D‐600 (METHOXYVERAPAMIL) ON THE RELEASE OF ADRENAL CATECHOLAMINES INDUCED BY ACETYLCHOLINE, HIGH POTASSIUM OR SODIUM DEPRIVATION

1976 • 68 citations

A New Activator Protein That Activates Tryptophan 5-Monooxygenase and Tyrosine 3-Monooxygenase in the Presence of Ca2+-, Calmodulin- dependent Protein Kinase

1981 • 65 citations

Stimulus secretion coupling in cultured chromaffin cells

1987 • 63 citations

Cholinergic Receptor‐Mediated Phosphorylation and Activation of Tyrosine Hydroxylase in Cultured Bovine Adrenal Chromaffin Cells

1986 • 50 citations

Effects of phorbol ester on tyrosine hydroxylase phosphorylation and activation in cultured bovine adrenal chromaffin cells.

1986 • 48 citations

Phosphatidylinositol Labelling in Response to Activation of Muscarinic Receptors in Bovine Adrenal Medulla

1981 • 40 citations

Inhibition of Calcium Uptake, Sodium Uptake, and Catecholamine Secretion by Methoxyverapamil (D600) in Primary Cultures of Adrenal Medulla Cells

1983 • 37 citations

Effects of Neuronal Activity on Inositol Phospholipid Metabolism in the Rat Autonomic Nervous System

1985 • 36 citations

Phospholipid metabolism and adrenal medullary activity. I. The effect of acetylcholine on tissue uptake and incorporation of orthophosphate-32P into nucleotides and phospholipids of bovine adrenal medulla.

1969 • 36 citations

Plasma Membrane and Chromaffin Granule Characteristics in Digitonin‐Treated Chromaffin Cells

1985 • 35 citations

Muscarine increases tyrosine 3-monooxygenase activity and phospholipid metabolism in the superior cervical ganglion of the rat.

1984 • 26 citations