Aging is associated with a diffuse impairment of forebrain cholinergic neurons

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

1983 • 1,898 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum

1981 • 535 citations

Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase

1988 • 496 citations

Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain

1984 • 454 citations

Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum

1983 • 359 citations

VARIATION WITH AGE IN THE VOLUMES OF GREY AND WHITE MATTER IN THE CEREBRAL HEMISPHERES OF MAN: MEASUREMENTS WITH AN IMAGE ANALYSER

1980 • 349 citations

Animal models of Alzheimer's disease: experimental cholinergic denervation

1988 • 340 citations

Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats

1989 • 335 citations

Identification of central cholinergic neurons containing both choline acetyltransferase and acetylcholinesterase and of central neurons containing only acetylcholinesterase

1983 • 335 citations

Central neurotransmitters and aging

1980 • 297 citations

Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase

1984 • 285 citations

The aging human brain

1985 • 248 citations

Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies

1985 • 247 citations

The anatomy of the CNS cholinergic neurons

1984 • 207 citations

Senile Dementia of the Alzheimer Type

1985 • 178 citations

The effect of advanced old age on the neurone content of the cerebral cortex

1983 • 152 citations

Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat

1986 • 136 citations

Muscarinic and dopaminergic receptors in the aging human brain

1987 • 130 citations

Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons

1988 • 127 citations

Age and sex-dependent decreases in ChAT in basal forebrain nuclei

1986 • 126 citations

Changes in nerve cells of the nucleus basalis of Meynert in Alzheimer's disease and their relationship to ageing and to the accumulation of lipofuscin pigment

1984 • 116 citations

Evidence that punctate intracerebral administration of 6-hydroxydopamine fails to produce selective neuronal degeneration

1974 • 111 citations

Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months

1985 • 111 citations

Age‐related shrinkage of cortically projecting cholinergic neurons: A selective effect

1987 • 101 citations

Regional analysis of age-related changes in the cholinergic system of the hippocampal formation and basal forebrain of the rat

1987 • 91 citations

Age-dependent loss and compensatory changes of septohippocampal cholinergic neurons in two rat strains differing in longevity and response to stress

1987 • 88 citations

Stability of neuronal number in the human nucleus basalis of Meynert with age

1984 • 72 citations

Age-impaired impulse flow from nucleus basalis to cortex

1985 • 70 citations

The Cholinergic System in Aging

1987 • 70 citations

Acetylcholinesterase and catecholamine distribution in the locus ceruleus of the rat

1980 • 63 citations

Age-dependent loss of cholinergic neurones in basal ganglia of rats

1988 • 46 citations

Dendritic length in aged rats' occipital cortex: An environmentally induced response

1981 • 42 citations

Strain-dependent variations in the number of forebrain cholinergic neurons

1985 • 36 citations

Lesions of the Nucleus Basalis in the Rat: Functional Changes

1985 • 13 citations

Quantitative pharmacohistochemistry of acetylcholinesterase in neostriatum of inbred strains of mice

1986 • 12 citations

A genetic study of neostriatal cholinergic neurones in C57BL/6 and DBA/2 mice.

1987 • 5 citations