Receptor and effector interactions of G_s Functional studies with antibodies to the α_s carboxyl‐terminal decapeptide

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.

1983 • 380 citations

Human cDNA clones for four species of G alpha s signal transduction protein.

1986 • 370 citations

Signal transduction by guanine nucleotide binding proteins

1987 • 362 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

Molecular basis for two forms of the G protein that stimulates adenylate cyclase.

1986 • 319 citations

[8] Use of glutaraldehyde as a coupling agent for proteins and peptides

1980 • 313 citations

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

1986 • 291 citations

Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase

1975 • 276 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

G protein multiplicity in eukaryotic signal transduction systems

1988 • 267 citations

Purification of the catalyst of adenylate cyclase.

1986 • 259 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

Gross Conformation of Rabbit 7 S γ-Immunoglobulin and Its Papain-cleaved Fragments

1965 • 212 citations

Molecular Cloning of Complementary DNA for the Alpha Subunit of the G Protein that Stimulates Adenylate Cyclase

1985 • 209 citations

Family of G protein α chains: amphipathic analysis and predicted structure of functional domains

1986 • 197 citations

Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.

1986 • 177 citations

Carboxyl Rerminal Domain of G _sα Specifies Coupling of Receptors to Stimulation of Adenylyl Cyclase

1988 • 174 citations

Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.

1977 • 173 citations

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.

1986 • 158 citations

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go

1988 • 153 citations

Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.

1986 • 148 citations

Primary structure of the α‐subunit of bovine adenylate cyclase‐stimulating G‐protein deduced from the cDNA sequence

1986 • 142 citations

Catalytic unit of adenlyate cyclase: purification and identification by affinity crosslinking.

1985 • 115 citations

Binding of 5′-Guanylyl-Imidodiphosphate to Turkey Erythrocyte Membranes and Effects on β-Adrenergic-activated Adenylate Cyclase

1974 • 103 citations

Identification by molecular cloning of two forms of the α‐subunit of the human liver stimulatory (G_s) regulatory component of adenylyl cyclase

1986 • 96 citations

Sequence analysis of bovine retinal S‐antigen

1986 • 92 citations

The amino acid sequence of elongation factor Tu of Escherichia coli. The complete sequence.

1981 • 77 citations

Characteristics of the guanine nucleotide regulatory component of adenylate cyclase in human erythrocyte membranes

1980 • 77 citations

An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function.

1988 • 76 citations

The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes.

1988 • 74 citations

Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates

1988 • 65 citations

Identification of the lesion in the stimulatory GTP‐binding protein of the uncoupled S49 lymphoma

1987 • 62 citations

The G protein beta 2 complementary DNA encodes the beta 35 subunit.

1987 • 47 citations

Role of the β-Adrenergic Receptor in the Regulation of Adenylate Cyclase

1984 • 20 citations