Activation of BMK1 via Tyrosine 1062 in RET by GDNF and MEN2A Mutation

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases

1999 • 518 citations

GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

1999 • 469 citations

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

1998 • 446 citations

Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase

1996 • 445 citations

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

1988 • 434 citations

Primary Structure of BMK1: A New Mammalian MAP Kinase

1995 • 345 citations

Mechanism of Activation of the ret Proto-oncogene by Multiple Endocrine Neoplasia 2A Mutations

1995 • 336 citations

RET Proto-Oncogene in the Development of Human Cancer

1999 • 333 citations

Signaling Complexes and Protein-Protein Interactions Involved in the Activation of the Ras and Phosphatidylinositol 3-Kinase Pathways by the c-Ret Receptor Tyrosine Kinase

2000 • 252 citations

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

2000 • 222 citations

Transforming Ability of MEN2A-RET Requires Activation of the Phosphatidylinositol 3-Kinase/AKT Signaling Pathway

2000 • 219 citations

The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ

1996 • 199 citations

A Mutation at Tyrosine 1062 in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins

1996 • 188 citations

MEKK3 Directly Regulates MEK5 Activity as Part of the Big Mitogen-activated Protein Kinase 1 (BMK1) Signaling Pathway

1999 • 187 citations

cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily.

1993 • 155 citations

Big Mitogen-activated Kinase Regulates Multiple Members of the MEF2 Protein Family

2000 • 152 citations

Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

1999 • 118 citations

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.

1996 • 112 citations

A Two-Hit Model for Development of Multiple Endocrine Neoplasia Type 2B by RET Mutations

2000 • 67 citations

Characterization of the Promoter Region of the Human RFP Gene

1999 • 9 citations