CD40-CD40L Interactions in Atherosclerosis

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis

1995 • 3,361 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

1998 • 2,047 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

Protective Role of Interleukin-10 in Atherosclerosis

1999 • 805 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

1997 • 737 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.

1998 • 525 citations

Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina

1999 • 504 citations

Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation.

1997 • 499 citations

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

1997 • 493 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.

1995 • 481 citations

P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice

2000 • 472 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Monocyte Chemoattractant Protein-1 Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

1999 • 452 citations

Requirement for CD154 in the progression of atherosclerosis

1999 • 437 citations

Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.

1995 • 368 citations

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

2000 • 353 citations

Regulation of Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells by T Lymphocytes

1997 • 342 citations

Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice

1999 • 340 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.

1997 • 330 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

CD40-CD40 Ligand: A Multifunctional Receptor-Ligand Pair

1996 • 326 citations

Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals.

1995 • 280 citations

Deficiency of Inflammatory Cell Adhesion Molecules Protects Against Atherosclerosis in Mice

1997 • 279 citations

Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype

2000 • 263 citations

Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.

1998 • 243 citations

Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation

1995 • 230 citations

T lymphocytes in aortic and coronary intimas. Their potential role in atherogenesis.

1988 • 226 citations

Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis

1999 • 219 citations

BLOCKADE OF THE CD40-CD40 LIGAND PATHWAY POTENTIATES THE CAPACITY OF DONOR-DERIVED DENDRITIC CELL PROGENITORS TO INDUCE LONG-TERM CARDIAC ALLOGRAFT SURVIVAL1,2

1997 • 215 citations

CD40 Ligation Induces Tissue Factor Expression in Human Vascular Smooth Muscle Cells

2000 • 157 citations

Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis

2000 • 154 citations

Phase I clinical trial of a monoclonal antibody against CD40-ligand (IDEC-131) in patients with systemic lupus erythematosus.

2001 • 147 citations

CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive β-chemokines

1998 • 126 citations

Ligation of CD40 Activates Interleukin 1β-converting Enzyme (Caspase-1) Activity in Vascular Smooth Muscle and Endothelial Cells and Promotes Elaboration of Active Interleukin 1β

1997 • 123 citations

CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells.

1997 • 118 citations

CD40 AND CD40 LIGAND (CD154) ARE COEXPRESSED ON MICROVESSELS IN VIVO IN HUMAN CARDIAC ALLOGRAFT REJECTION1,2

1997 • 117 citations

Anti-CD40 Antibody Induces Antitumor and Antimetastatic Effects: The Role of NK Cells

2001 • 108 citations

Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions

2000 • 101 citations

PREVENTION OF CHRONIC REJECTION IN MOUSE AORTIC ALLOGRAFTS BY COMBINED TREATMENT WITH CTLA4-Ig AND ANTI-CD40 LIGAND MONOCLONAL ANTIBODY1,2

1997 • 96 citations

Blockade of CD40–CD40 Ligand Interactions Protects against Radiation-Induced Pulmonary Inflammation and Fibrosis

1998 • 84 citations

CD40: A cytokine receptor in search of a ligand

1990 • 82 citations

Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.

1998 • 78 citations

CD40 ligation for immunotherapy of solid tumours

2001 • 68 citations

Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesions

2001 • 62 citations

Proinflammatory Cytokines and CD40 Ligand Enhance Cross-Presentation and Cross-Priming Capability of Human Dendritic Cells Internalizing Apoptotic Cancer Cells

2001 • 61 citations

Immunologic Reconstitution Following Bone Marrow Transplantation for X-Linked Hyper IgM Syndrome

2001 • 46 citations

Regulation of the Thrombotic Potential of Atheroma

1999 • 31 citations

Absence of CD40 Signaling Is Associated With an Increase in Intimal Thickening After Arterial Injury

2001 • 29 citations

CD40/CD40 Ligand Interactions Are Critical for Elicitation of Autoimmune-Mediated Fibrosis in the Lung

2001 • 27 citations