Decreased base excision repair and increased helicase activity in Alzheimer's disease brain

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

The Bloom's syndrome gene product is homologous to RecQ helicases

1995 • 1,371 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

1997 • 938 citations

Cancer risk and oxidative DNA damage in man

1996 • 936 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

1998 • 677 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

DNA Mismatch Correction in a Defined System

1989 • 551 citations

Oxidative damage to DNA in mammalian chromatin

1992 • 546 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

1998 • 467 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

1996 • 435 citations

Regional membrane phospholipid alterations in Alzheimer's disease.

1998 • 422 citations

Radiation-induced DNA Damage and Its Repair

1987 • 405 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

DNA HELICASES

1990 • 351 citations

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

1994 • 321 citations

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

1997 • 316 citations

[2] Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection

1994 • 303 citations

Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

1999 • 283 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Modification of DNA bases in mammalian chromatin by radiation-generated free radicals

1990 • 255 citations

Cerebrospinal fluid F₂‐isoprostane levels are increased in Alzheimer's disease

1998 • 241 citations

Effect of DNA polymerase I and DNA helicase II on the turnover rate of UvrABC excision nuclease.

1985 • 223 citations

Involvement of helicase II (uvrD gene product) and DNA polymerase I in excision mediated by the uvrABC protein complex.

1985 • 222 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A

1998 • 208 citations

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

1990 • 196 citations

The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation

1998 • 165 citations

An endonuclease activity of Escherichia coli that specifically removes 8-hydroxyguanine residues from DNA

1991 • 149 citations

Evidence for an imino intermediate in the T4 endonuclease V reaction

1993 • 143 citations

Studies on the Catalytic Mechanism of Five DNA Glycosylases

1995 • 142 citations

Kunitz Protease Inhibitor-Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease

1992 • 137 citations

The Catalytic Mechanism of Fpg Protein

1995 • 124 citations

The presence of nuclear and mitochondrial uracil-DNA glycosylase in extracts of human KB cells.

1980 • 109 citations

Large-scale purification and characterization of the Escherichia coli rep gene product

1989 • 108 citations

The Amyloid β Protein Induces Oxidative Damage of Mitochondrial DNA

1997 • 106 citations

DNA repair in Escherichia coli: identification of the uvrD gene product.

1982 • 92 citations

Deficient repair of DNA lesions in Alzheimer's disease fibroblasts

1985 • 89 citations

Identification of the uvrD gene product of Escherichia coli as DNA helicase II and its induction by DNA-damaging agents.

1984 • 86 citations

An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA

1991 • 84 citations

Alzheimer's disease cells exhibit defective repair of alkylating agent—induced DNA damage

1987 • 67 citations

The Escherichia coli uvrD gene is inducible by DNA damage

1983 • 53 citations

Alzheimer disease fibroblasts are hypersensitive to the lethal effects of a DNA-damaging chemical

1986 • 49 citations

Deficiency of 8-hydroxyguanine dna endonuclease activity and accumulation of the 8-hydroxyguanine in mutator mutant (mutM) of Escherichia coli

1992 • 42 citations

Identification of the gene for DNA helicase II of Escherichia coli

1983 • 42 citations

Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down Syndrome and Alzheimer's disease

1998 • 40 citations

Transcriptional control of the uvrD gene of Escherichia coli

1983 • 38 citations

Molecular cloning of the uvrD gene of Escherichia coli that controls ultraviolet sensitivity and spontaneous mutation frequency

1981 • 36 citations

Comparison of Incorporation and Extension of Nucleotides in vitro opposite 8‐Hydroxyguanine (7,8‐Dihydro‐8‐oxoguanine) in Hot Spots of the c‐Ha‐ras Gene

1995 • 31 citations

Decreased DNA repair in familial Alzheimer's disease

1989 • 25 citations

A random sequencing approach for placing markers on the physical map ofMycoplasma genitalium

1991 • 18 citations

recA + gene-dependent regulation of a urvD::lacZ fusion in Escherichia coli K12

1983 • 15 citations

Studies on DNA Repair Defects in Degenerative Brain Disease

1993 • 10 citations

DNA repair: Pathways and defects

1980 • 10 citations

Mapping to the point

1995 • 7 citations