Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Differential expression of orexin receptors 1 and 2 in the rat brain

2001 • 1,593 citations

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1996 • 1,301 citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

1999 • 1,028 citations

Distribution of orexin receptor mRNA in the rat brain

1998 • 982 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems

1998 • 687 citations

Presynaptic and Postsynaptic Actions and Modulation of Neuroendocrine Neurons by a New Hypothalamic Peptide, Hypocretin/Orexin

1998 • 562 citations

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

1998 • 518 citations

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

1999 • 502 citations

Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord

2001 • 457 citations

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

1999 • 438 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

The lateral hypothalamic area revisited: Ingestive behavior

1996 • 400 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action1This study was presented in part at the 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA, in November 1998.1

1999 • 337 citations

Independent Feeding and Metabolic Actions of Orexins in Mice

1998 • 325 citations

Feeding response to central orexins

1999 • 316 citations

Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

1999 • 309 citations

Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse

1978 • 257 citations

The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism

1993 • 250 citations

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

1996 • 232 citations

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

1997 • 206 citations

Leptin Rapidly Lowers Food Intake and Elevates Metabolic Rates in Lean and ob/ob Mice ,

1997 • 191 citations

Orexin A-like immunoreactivity in the rat brain

1999 • 181 citations

Neuropeptides and obesity

2000 • 171 citations

Effects of Leptin on Corticotropin-Releasing Factor (CRF) Synthesis and CRF Neuron Activation in the Paraventricular Hypothalamic Nucleus of Obese (ob/ob) Mice

1998 • 164 citations

Down regulation of the prepro-orexin gene expression in genetically obese mice

1999 • 156 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin

1998 • 133 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting

1999 • 128 citations

Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus

2001 • 98 citations

Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area

1999 • 86 citations

Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and Zucker diabetic fatty rats and effects of rosiglitazone

2000 • 74 citations

Opposite Regulation of Hypothalamic Orexin and Neuropeptide Y Receptors and Peptide Expressions in Obese Zucker Rats

2001 • 55 citations

Oxygen Consumption and Body Fat Content of Young Lean and Obese (OB/OB) Mice

1978 • 49 citations

Reduced hypothalamic neurotensin concentrations in the genetically obese diabetic () mouse: Possible relationship to obesity

1991 • 41 citations

Neuropeptide Y and Corticotropin-Releasing Hormone Concentrations within Specific Hypothalamic Regions of Lean but Not Ob/ob Mice Respond to Food-Deprivation and Refeeding

1998 • 40 citations

Increased β-endorphin and dynorphin concentrations in discrete hypothalamic regions of genetically obese (ob/ob) mice

1991 • 34 citations

Effects of Leptin on Corticotropin-Releasing Factor (CRF) Synthesis and CRF Neuron Activation in the Paraventricular Hypothalamic Nucleus of Obese (ob/ob) Mice

1998 • 30 citations

Down-regulated NPY receptor subtype-5 mRNA expression in genetically obese mouse brain

1998 • 30 citations

Elevated neuronal c-Fos-like immunoreactivity and messenger ribonucleic acid (mRNA) in genetically obese (ob/ob) mice

1994 • 26 citations

Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats

1997 • 24 citations

Brain administration of OB protein (leptin) inhibits neuropeptide-Y-induced feeding in ob/ob mice

1998 • 23 citations

Altered c-fos expression in autonomic regulatory centers of genetically obese (ob/ob) mouse brain

1998 • 19 citations

Dexamethasone rapidly increases hypothalamic neuropeptide Y secretion in adrenalectomized ob/ob mice

1996 • 16 citations

Reduced Brain Norepinephrine Metabolism in Obese (ob/ob) Mice is Not Normalized by Tyrosine Supplementation

1986 • 9 citations