Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and Zucker diabetic fatty rats and effects of rosiglitazone

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

1999 • 1,028 citations

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

1998 • 995 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormonein Vivo

1998 • 555 citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

1998 • 554 citations

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

1997 • 524 citations

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

1999 • 502 citations

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

1999 • 438 citations

Thiazolidinediones: a new class of antidiabetic drugs

1999 • 429 citations

Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats

1999 • 320 citations

Feeding response to central orexins

1999 • 316 citations

Hypothalamic orexin expression: modulation by blood glucose and feeding.

1999 • 313 citations

The Prevention and Treatment of Obesity: Application to type 2 diabetes

1997 • 270 citations

Leptin Receptor‐ and STAT3‐Immunoreactivities in Hypocretin/Orexin Neurones of the Lateral Hypothalamus¹

1999 • 226 citations

Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord☆

1999 • 217 citations

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

1997 • 206 citations

Rosiglitazone

1999 • 188 citations

Substitution at Codon 269 (Glutamine → Proline) of the Leptin Receptor (OB-R) cDNA Is the Only Mutation Found in the Zucker Fatty (fa/fa) Rat

1996 • 186 citations

Distribution and quantification of immunoreactive orexin A in rat tissues

1999 • 177 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

1998 • 163 citations

Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats

2000 • 161 citations

Down regulation of the prepro-orexin gene expression in genetically obese mice

1999 • 156 citations

Widespread Distribution of Orexin in Rat Brain and Its Regulation upon Fasting

1999 • 152 citations

Increased Hypothalamic Neuropeptide Y Concentrations in Diabetic Rat

1988 • 120 citations

Evidence for a Central Mechanism of Obesity in the Zucker Rat: Role of Neuropeptide Y and Leptin

1997 • 93 citations

STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats

1999 • 77 citations

Increased hypothalamic neuropeptide Y concentrations in diabetic rat

1988 • 60 citations

Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC‐555

1998 • 56 citations

Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y

1997 • 55 citations

The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC‐555 treatment

1998 • 45 citations

Determination, Using Microdialysis, of Hypothalamic Serotonin Variations in Response to Different Macronutrients

1998 • 40 citations

The significance of nucleus raphe dorsalis and centralis for thermoafferent signal transmission to the preoptic area of the rat

1985 • 29 citations