Identification of Two Pairs of Spatially Approximated Residues within the Carboxyl Terminus of Secretin and Its Receptor

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Electron-crystallographic Refinement of the Structure of Bacteriorhodopsin

1996 • 961 citations

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber

1997 • 639 citations

Arrangement of rhodopsin transmembrane α-helices

1997 • 449 citations

Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family

1993 • 291 citations

Secretin and vasoactive intestinal peptide receptors: Members of a unique family of G protein–coupled receptors

1998 • 217 citations

Parathyroid Hormone-Receptor Interactions Identified Directly by Photocross-linking and Molecular Modeling Studies

1998 • 184 citations

Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptide Receptors. STUDIES OF CHIMERIC RECEPTORS

1995 • 169 citations

The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).

1994 • 145 citations

Evidence for a Ligand Interaction Site at the Amino-Terminus of the Parathyroid Hormone (PTH)/PTH-related Protein Receptor from Cross-linking and Mutational Studies

1998 • 109 citations

Relationship Between Native and Recombinant Cholecystokinin Receptors

1996 • 104 citations

Use of N,O‐bis‐Fmoc‐<scp>d</scp>‐Tyr‐ONSu for introduction of an oxidative iodination site into cholecystokinin family peptides

1988 • 103 citations

Multiple Extracellular Loop Domains Contribute Critical Determinants for Agonist Binding and Activation of the Secretin Receptor

1996 • 97 citations

Ceramide triggers intracellular calcium release via the IP₃ receptor inXenopus laevisoocytes

1999 • 87 citations

Demonstration of a Direct Interaction between Residue 22 in the Carboxyl-terminal Half of Secretin and the Amino-terminal Tail of the Secretin Receptor Using Photoaffinity Labeling

1999 • 85 citations

Analysis of the carbohydrate composition of the pancreatic plasmalemmal glycoprotein affinity labeled by short probes for the cholecystokinin receptor.

1987 • 81 citations

Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking

1997 • 81 citations

The C-terminus ends of secretin and VIP interact with the N-terminal domains of their receptors

1996 • 80 citations

Direct Identification of a Second Distinct Site of Contact between Cholecystokinin and Its Receptor

1998 • 80 citations

Properties of Chimeric Secretin and VIP Receptor Proteins Indicate the Importance of the N-Terminal Domain for Ligand Discrimination

1995 • 79 citations

A ¹H‐NMR study of the solution conformation of secretin resonance assignment and secondary structure

1987 • 78 citations

The arrangement of the transmembrane helices in the secretin receptor family of G‐protein‐coupled receptors

1997 • 76 citations

Intrinsic photoaffinity labeling of native and recombinant rat pancreatic secretin receptors

1993 • 72 citations

Arginine 186 in the Extracellular N-Terminal Region of the Human Parathyroid Hormone 1 Receptor Is Essential for Contact with Position 13 of the Hormone

1998 • 72 citations

The Amino-Terminal Fragment of the Adenylate-Cyclase Activating Polypeptide (Pacap) Receptor Functions as a High-Affinity Pacap Finding Domain

1995 • 70 citations

Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis.

1998 • 64 citations

Identification of an Interaction between Residue 6 of the Natural Peptide Ligand and a Distinct Residue within the Amino-terminal Tail of the Secretin Receptor

1999 • 63 citations

A Putative Selectivity Filter in the G-protein-coupled Receptors for Parathyroid Hormone and Secretin

1996 • 50 citations

Mutational Analysis of Extracellular Cysteine Residues of Rat Secretin Receptor Shows that Disulfide Bridges are Essential for Receptor Function

1997 • 47 citations

Importance of disulfide bonds in receptors for vasoactive intestinal peptide and secretin in rat pancreatic plasma membranes

1984 • 43 citations

The entire vasoactive intestinal polypeptide molecule is required for the activation of the vasoactive intestinal polypeptide receptor: functional and binding studies on opossum internal anal sphincter smooth muscle.

1993 • 41 citations

Role of N-Linked Glycosylation on the Function and Expression of the Human Secretin Receptor

1999 • 40 citations

A disulfide bond between conserved cysteines in the extracellular loops of the human VIP receptor is required for binding and activation

1997 • 39 citations

Interaction of Amino Acid Residues at Positions 8–15 of Secretin with the N‐Terminal Domain of the Secretin Receptor

1996 • 38 citations

Direct Identification of Two Contact Sites for Parathyroid Hormone (PTH) in the Novel PTH-2 Receptor using Photoaffinity Cross-Linking1

1999 • 36 citations

NMR Spectroscopic Evidence That Helodermin, unlike Other Members of the Secretin/VIP Family of Peptides, Is Substantially Structured in Water

1996 • 29 citations

Conformation of peptides of the secretin-VIP-glucagon family in solution

1986 • 24 citations

Proposed arrangement of the seven transmembrane helices in the secretin receptor family.

1998 • 21 citations

Chemical properties of the histidine residue of secretin: evidence for a specific intramolecular interaction

1989 • 18 citations

The C‐terminal part of VIP is important for receptor binding and activation, as evidenced by chimeric constructs of VIP/secretin

1997 • 18 citations

Conformation of secretin in dimethyl sulfoxide solution

1989 • 15 citations

Speculations on the Mechanism of Hormone-Receptor Interactions of the Secretin/Glucagon Family of Polypeptide Hormones Derived from Computational Structural Studies

2006 • 7 citations

Receptors and channels

2004 • 7 citations