Effects of cytochrome p450 2E1 modulators on the pharmacokinetics of chlorzoxazone and 6-hydroxychlorzoxazone in rats

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1991 • 1,173 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

1989 • 488 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

Purification and characterization of hepatic microsomal cytochrome P-450

1990 • 379 citations

Cytochrome P450IIe1: Roles in Nitrosamine Metabolism and Mechanisms of Regulation

1990 • 361 citations

Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.

1983 • 337 citations

Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites

1991 • 260 citations

The metabolism of acetone in rat.

1984 • 258 citations

Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes.

1985 • 256 citations

Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system

1990 • 202 citations

Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

1986 • 173 citations

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics

1994 • 167 citations

Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a

1986 • 158 citations

Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans

1993 • 156 citations

Metabolism of N-nitrosodialkylamines by human liver microsomes.

1988 • 149 citations

Modulation of rat hepatic microsomal monooxygenase enzymes and cytotoxicity by diallyl sulfide

1991 • 129 citations

The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol

1982 • 127 citations

Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P450 2E1

1993 • 125 citations

Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone

1993 • 117 citations

Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1

1995 • 111 citations

Turnover of membrane proteins: Kinetics of induction and degradation of seven forms of rat liver microsomal cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase

1984 • 100 citations

Decrease in Cytochrome P4502E1 as Assessed by the Rate of Chlorzoxazone Hydroxylation in Alcoholics during the Withdrawal Phase

1995 • 80 citations

[33] Induction protocols for cytochromes P450IIIA in Vivo and in primary cultures of animal and human hepatocytes

1991 • 69 citations

Relationship between cytochrome P450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor

1994 • 61 citations

Physiological disposition and metabolic fate of chlorzoxazone (paraflex) in man.

1960 • 54 citations

Metabolism and activation of N-nitrosodimethylamine by hamster and rat microsomes: comparative study with weanling and adult animals.

1987 • 54 citations

Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes. off.

1995 • 46 citations

Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.

1992 • 39 citations

Identification of a human liver cytochrome P-450 exhibiting catalytic and immunochemical similarities to cytochrome P-450 3a of rabbit liver

1987 • 32 citations

Dominant role of cytochrome P-450 2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane.

1992 • 19 citations

Relation of disposition kinetics to pharmacological effect of intravenous administration of chlorzoxazone in rats.

1990 • 6 citations