A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Molecular cloning of an enhancer binding protein:Isolation by screening of an expression library with a recognition site DNA

1988 • 677 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II

1990 • 550 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.

1988 • 535 citations

Characterization of a “silencer” in yeast: A DNA sequence with properties opposite to those of a transcriptional enhancer

1985 • 531 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

1988 • 432 citations

The human β-interferon gene enhancer is under negative control

1986 • 395 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80

1987 • 349 citations

A New Member of the Leucine Zipper Class of Proteins that Binds to the HLA DRα Promoter

1990 • 286 citations

HUMAN CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND PROTEINS

1988 • 277 citations

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X

1988 • 275 citations

Glucocorticoid Receptor Binding to a Specific DNA Sequence Is Required for Hormone-Dependent Repression of Pro-Opiomelanocortin Gene Transcription

1989 • 265 citations

Drosophila Krüppel protein is a transcriptional represser

1990 • 228 citations

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins.

1993 • 227 citations

Analysis of Krüppel protein distribution during early Drosophila development reveals posttranscriptional regulation

1987 • 222 citations

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

1989 • 192 citations

In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome

1991 • 175 citations

MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain.

1990 • 171 citations

Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts.

1986 • 159 citations

Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription.

1989 • 156 citations

Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.

1992 • 148 citations

Molecular cloning of sequence-specific DNA binding proteins using recognition site probes.

1989 • 142 citations

Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.

1991 • 125 citations

Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding.

1992 • 119 citations

B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

1988 • 118 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 107 citations

Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene.

1988 • 106 citations

Sequence-specific interactions of nuclear factors with conserved sequences of human class II major histocompatibility complex genes.

1987 • 103 citations

A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.

1990 • 98 citations

Regulation of the expression of multiple class II genes in murine B cells by B cell stimulatory factor-1 (BSF-1).

1986 • 70 citations

In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma.

1992 • 69 citations

Active suppression of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells.

1988 • 59 citations

NF-X2 that binds to the DRA X2-box is activator protein 1. Expression cloning of c-Jun.

1990 • 57 citations

Postinduction repression of the beta-interferon gene is mediated through two positive regulatory domains.

1990 • 56 citations

Transcription of a subset of human class II major histocompatibility complex genes is regulated by a nucleoprotein complex that contains c-fos or an antigenically related protein.

1991 • 52 citations

The E alpha promoter: a linker-scanning analysis.

1991 • 49 citations

An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP.

1991 • 47 citations

Sequences And Factors: A Guide To Mhc Class-Ii Transcription

1992 • 35 citations

A cDNA for a Human Cyclic AMP Response Element-Binding Protein Which Is Distinct from CREB and Expressed Preferentially in Brain

1990 • 28 citations

Regulation Of Major Histocompatibility Complex Class-Ii Genes: X, Y And Other Letters Of The Alphabet

1990 • 25 citations

Only Two of the Five Zinc Fingers of the Eukaryotic Transcriptional Repressor PRDI-BF1 Are Required for Sequence-Specific DNA Binding

1992 • 20 citations

The B cell-specific nuclear factor OTF-2 positively regulates transcription of the human class II transplantation gene, DRA.

1992 • 15 citations

Current concepts in DRA gene regulation

1993 • 15 citations

MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain

1990 • 10 citations

Human Class Ii Major Histocompatibility Complex Genes And Proteins

1988 • 9 citations

Interferon-γ Induces Transcription and Differential Expression of MHC Genes in Rat Insulinoma Cell Line RINm5F

1989 • 7 citations

The B cell-specific nuclear factor OTF-2 positively regulates transcription of the human class II transplantation gene, DRA

1992 • 3 citations