Tumor Necrosis Factor-alpha and Lipopolysaccharide Enhance Interferon-Induced Antichlamydial Indoleamine Dioxygenase Activity Independently

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

1986 • 389 citations

Indoleamine 2,3-dioxygenase. Purification and some properties

1978 • 362 citations

Gamma Interferon Priming of Mouse and Human Macrophages for Induction of Tumor Necrosis Factor Production by Bacterial Lipopolysaccharide

1987 • 212 citations

Interferon-lnduced Indoleamine 2,3-Dioxygenase Activity in Human Mononuclear Phagocytes

1989 • 187 citations

[26] Indoleamine 2,3-dioxygenase

1987 • 176 citations

Interferon-γ suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophan

1986 • 161 citations

Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

1994 • 145 citations

Competition between Chlamydia psittaci and L cells for host isoleucine pools: a limiting factor in chlamydial multiplication

1975 • 139 citations

Interferon-Induced Indoleamine 2,3-Dioxygenase Activity InhibitsChlamydia psittaciReplication in Human Macrophages

1989 • 136 citations

Inhibition of Chlamydia pneumoniae growth in HEp-2 cells pretreated with gamma interferon and tumor necrosis factor alpha

1995 • 117 citations

Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice

1993 • 113 citations

Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin.

1986 • 105 citations

Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment.

1990 • 103 citations

Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells

1993 • 103 citations

Anti‐parasitic effector mechanisms in human brain tumor cells: Role of interferon‐γ and tumor necrosis factor‐α

1996 • 90 citations

Extinguishing maternal immune responses during pregnancy: implications for immunosuppression

2001 • 84 citations

Interleukin-1 Enhances Indoleamine 2,3-Dioxygenase Activity by Increasing Specific mRNA Expression in Human Mononuclear Phagocytes

1995 • 79 citations

Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages

1989 • 76 citations

Membrane molecules which trigger the production of interleukin‐1 and tumor necrosis factor‐α by lipopolysaccharide‐stimulated human monocytes

1992 • 63 citations

Rapid separation of tryptophan, kynurenines, and indoles using reversed-phase high-performance liquid chromatography

1979 • 63 citations

Lymphokine-mediated microbistatic mechanisms restrict Chlamydia psittaci growth in macrophages.

1982 • 62 citations

Reversion of the antichlamydial effect of tumor necrosis factor by tryptophan and antibodies to beta interferon

1989 • 58 citations

Upregulation of interferon-induced indoleamine 2,3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1

1995 • 55 citations

THE ROLE OF ENDOGENOUS IFN-γ, TNF-α AND IL-10 IN LPS-INDUCED NITRIC OXIDE RELEASE IN A MOUSE MODEL

1998 • 54 citations

Potentiation of interferon-mediated inhibition of Chlamydia infection by interleukin-1 in human macrophage cultures

1995 • 53 citations

Potentiation of Interferon-Induced Indoleamine 2,3-Dioxygenase mRNA in Human Mononuclear Phagocytes by Lipopolysaccharide and Interleukin-1

1997 • 42 citations

Effect of interferon on a primary conjunctival epithelial cell model of trachoma.

1991 • 41 citations

Tumor necrosis factor alpha activity in genital tract secretions of guinea pigs infected with chlamydiae

1995 • 37 citations

The signal transduction mechanism responsible for gamma interferon-induced indoleamine 2,3-dioxygenase gene expression

1994 • 31 citations