The Epstein–Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

DNA sequence and expression of the B95-8 Epstein—Barr virus genome

1984 • 2,039 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

Mechanism and regulation of mRNA polyadenylation

1997 • 762 citations

Human growth hormone as a reporter gene in regulation studies employing transient gene expression.

1986 • 667 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

Primary structure of the herpesvirus saimiri genome

1992 • 440 citations

Modulation of firefly luciferase stability and impact on studies of gene regulation

1991 • 437 citations

Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

1989 • 417 citations

Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.

1975 • 390 citations

Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

1986 • 359 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

In vitro polyadenylation is stimulated by the presence of an upstream intron.

1990 • 313 citations

Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA

1990 • 312 citations

The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.

1994 • 305 citations

Nuclear Export Receptors: From Importin to Exportin

1997 • 282 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect

1994 • 257 citations

Human Growth Hormone as a Reporter Gene in Regulation Studies Employing Transient Gene Expression

1986 • 223 citations

Recombinant Epstein-Barr virus with small RNA (EBER) genes deleted transforms lymphocytes and replicates in vitro.

1991 • 220 citations

A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing.

1992 • 207 citations

Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.

1991 • 200 citations

The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation

1996 • 189 citations

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection

1994 • 189 citations

UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression

1994 • 171 citations

An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat.

1988 • 137 citations

Epstein-Barr virus bicistronic mRNAs generated by facultative splicing code for two transcriptional trans-activators.

1989 • 133 citations

Promiscuous trans activation of gene expression by an Epstein-Barr virus-encoded early nuclear protein

1986 • 128 citations

Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing

1992 • 125 citations

Regulation of herpes simplex virus poly (A) site usage and the action of immediate-early protein IE63 in the early-late switch

1996 • 119 citations

Genetic Relations between Varicella-Zoster Virus and Epstein-Barr Virus

1987 • 113 citations

The Epstein-Barr virus (EBV) early protein EB2 is a posttranscriptional activator expressed under the control of EBV transcription factors EB1 and R

1989 • 110 citations

Identification and mapping of Epstein-Barr virus early antigens and demonstration of a viral gene activator that functions in trans

1986 • 82 citations

Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA

1995 • 75 citations

Varicella-zoster virus open reading frame 4 encodes a transcriptional activator that is functionally distinct from that of herpes simplex virus homology ICP27

1994 • 71 citations

The Epstein-Barr virus immediate-early gene product, BMLF1, acts in trans by a posttranscriptional mechanism which is reporter gene dependent

1989 • 71 citations

The Epstein-Barr virus (EBV) early promoter DR contains a cis-acting element responsive to the EBV transactivator EB1 and an enhancer with constitutive and inducible activities

1989 • 54 citations

Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.

1993 • 53 citations

Epstein-Barr Virus SM Protein

1994 • 49 citations

Immediate early protein IE63 of herpes simplex virus type 1 binds RNA directly

1996 • 47 citations

Localization of the coding region for an Epstein-Barr virus early antigen and inducible expression of this 60-kilodalton nuclear protein in transfected fibroblast cell lines

1985 • 46 citations

Mapping of genes in BamHI fragment M of Epstein-Barr virus DNA that may determine the fate of viral infection

1986 • 43 citations

Disparate effects of two herpesviruses immediate-early gene trans-activators on the HIV-1 LTR

1989 • 35 citations

Herpesviruses: a study of parts

1990 • 18 citations

Characterization of Epstein–Barr Virus Recombinants with Deletions of theBamHI C Promoter

1996 • 17 citations