Array comparative genomic hybridization and its applications in cancer

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

Detection of large-scale variation in the human genome

2004 • 2,876 citations

Large-Scale Copy Number Polymorphism in the Human Genome

2004 • 2,542 citations

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

1998 • 2,266 citations

Circular binary segmentation for the analysis of array-based DNA copy number data

2004 • 2,261 citations

Replication validity of genetic association studies

2001 • 1,845 citations

Genome-wide analysis of DNA copy-number changes using cDNA microarrays

1999 • 1,445 citations

Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

2002 • 1,114 citations

Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances

1997 • 991 citations

Assembly of microarrays for genome-wide measurement of DNA copy number

2001 • 948 citations

Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma.

1987 • 884 citations

Assessing the impact of population stratification on genetic association studies

2004 • 805 citations

Determinants of BRAF Mutations in Primary Melanomas

2003 • 653 citations

A tiling resolution DNA microarray with complete coverage of the human genome

2004 • 644 citations

Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene

2000 • 598 citations

Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization

1993 • 561 citations

An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays

2004 • 558 citations

Analysis of array CGH data: from signal ratio to gain and loss of DNA regions

2004 • 527 citations

Impact of DNA amplification on gene expression patterns in breast cancer.

2002 • 498 citations

DNA microarrays for comparative genomic hybridization based on DOP‐PCR amplification of BAC and PAC clones

2003 • 480 citations

Unbiased Whole-Genome Amplification Directly From Clinical Samples

2003 • 418 citations

Evaluation of HER-2/neu Gene Amplification and Overexpression: Comparison of Frequently Used Assay Methods in a Molecularly Characterized Cohort of Breast Cancer Specimens

2002 • 393 citations

Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA

2004 • 373 citations

Genomic microarrays in human genetic disease and cancer

2003 • 372 citations

In situ analyses of genome instability in breast cancer

2004 • 354 citations

Hidden Markov models approach to the analysis of array CGH data

2004 • 351 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

A method for calling gains and losses in array CGH data

2004 • 315 citations

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas

2001 • 305 citations

Segmental duplications: an 'expanding' role in genomic instability and disease

2001 • 287 citations

Whole Genome Analysis of Genetic Alterations in Small DNA Samples Using Hyperbranched Strand Displacement Amplification and Array–CGH

2003 • 267 citations

Epigenetic lesions causing genetic lesions in human cancer

2000 • 256 citations

Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations

2004 • 241 citations

Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations

2003 • 240 citations

Telomere dysfunction provokes regional amplification and deletion in cancer genomes

2002 • 240 citations

Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors

2002 • 197 citations

Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome

2005 • 195 citations

Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer

2004 • 192 citations

Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors

2004 • 181 citations

Chromosomal Alterations in Ductal Carcinomas In Situ and Their In Situ Recurrences

2000 • 166 citations

Extensive Genomic Diversity in Pathogenic Escherichia coli and Shigella Strains Revealed by Comparative Genomic Hybridization Microarray

2004 • 160 citations

High-Resolution Global Profiling of Genomic Alterations with Long Oligonucleotide Microarray

2004 • 153 citations

Identification and validation of prognostic markers in breast cancer with the complementary use of array‐CGH and tissue microarrays

2005 • 149 citations

Exon Array CGH: Detection of Copy-Number Changes at the Resolution of Individual Exons in the Human Genome

2005 • 143 citations

Genomic Alterations in Primary Gastric Adenocarcinomas Correlate with Clinicopathological Characteristics and Survival

2004 • 140 citations

High-Resolution Mapping of Genotype-Phenotype Relationships in Cri du Chat Syndrome Using Array Comparative Genomic Hybridization

2005 • 139 citations

High resolution microarray comparative genomic hybridisation analysis using spotted oligonucleotides

2004 • 131 citations

Profiling Breast Cancer by Array CGH

2003 • 112 citations

High-Resolution Molecular Characterization of 15q11-q13 Rearrangements by Array Comparative Genomic Hybridization (Array CGH) with Detection of Gene Dosage

2004 • 109 citations

Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplifications

2005 • 106 citations

Detecting Gene Copy Number Fluctuations in Tumor Cells by Microarray Analysis of Genomic Representations

2000 • 104 citations

BAC microarray analysis of 15q11-q13 rearrangements and the impact of segmental duplications

2004 • 102 citations

Segmental Duplications: What's Missing, Misassigned, and Misassembled—and Should We Care?: Figure 1.

2001 • 102 citations

Degenerate Oligonucleotide Primed-Polymerase Chain Reaction-Based Array Comparative Genomic Hybridization for Extensive Amplicon Profiling of Breast Cancers

2001 • 100 citations

Genomic segmental polymorphisms in inbred mouse strains

2004 • 98 citations

A survey of homozygous deletions in human cancer genomes

2005 • 98 citations

Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array

2004 • 93 citations

DNA amplification method tolerant to sample degradation

2004 • 90 citations

Shaping of tumor and drug-resistant genomes by instability and selection

2003 • 87 citations

Mapping segmental and sequence variations among laboratory mice using BAC array CGH

2005 • 73 citations

Array-Based Comparative Genomic Hybridization from Formalin-Fixed, Paraffin-Embedded Breast Tumors

2005 • 71 citations

Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples

2004 • 66 citations

Chromosomal duplications in bacteria, fruit flies, and humans.

1996 • 63 citations

Evaluation of a whole‐genome amplification method based on adaptor‐ligation PCR of randomly sheared genomic DNA

2003 • 63 citations

DNA copy-number analysis of the 22q11 deletion-syndrome region using array-CGH with genomic and PCR-based targets

2004 • 60 citations

A versatile statistical analysis algorithm to detect genome copy number variation

2004 • 60 citations

Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects

1999 • 55 citations

Detecting single DNA copy number variations in complex genomes using one nanogram of starting DNA and BAC-array CGH

2004 • 48 citations

Analyses of brain tumor cell lines confirm a simple model of relationships among fluorescence in situ hybridization, DNA index, and comparative genomic hybridization

1997 • 34 citations

A new approach to species determination for yeast strains: DNA microarray‐based comparative genomic hybridization using a yeast DNA microarray with 6000 genes

2004 • 30 citations

Method for manufacturing whole‐genome microarrays by rolling circle amplification

2004 • 20 citations

Four-color CGH: A new method for quality control of comparative genomic hybridization

1999 • 18 citations

LM-PCR Permits Highly Representative Whole Genome Amplification of DNA Isolated From Small Number of Cells and Paraffin-Embedded Tumor Tissue Sections

2004 • 14 citations