Recent advances in identifying the functions of gangliosides

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Fibronectins: multifunctional modular glycoproteins.

1982 • 1,334 citations

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

1985 • 1,119 citations

A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.

1982 • 885 citations

Biosynthesis and Function of Gangliosides

1976 • 748 citations

[10] Gangliosides: Structure, isolation, and analysis

1982 • 705 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

Gangliosides and membrane receptors for cholera toxin

1973 • 536 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Detection of gangliosides that bind cholera toxin: Direct binding of 125I-labeled toxin to thin-layer chromatograms

1980 • 480 citations

Tissue Receptor for Cholera Exotoxin: Postulated Structure from Studies with G _M1 Ganglioside and Related Glycolipids

1973 • 461 citations

Role of membrane gangliosides in the binding and action of bacterial toxins

1982 • 396 citations

Activation of Adenylate Cyclase by Choleragen

1979 • 394 citations

Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts.

1985 • 335 citations

Biology of gangliosides: Neuritogenic and neuronotrophic properties

1984 • 314 citations

Deactivation of Cholera Toxin by a Sialidase-Resistant Monosialosylganglioside

1973 • 302 citations

Über die Ganglioside, eine neue Gruppe von zuckerhaltigen Gehirnlipoiden

1942 • 301 citations

Selective Inhibition of Fibronectin-Mediated Cell Adhesion by Monoclonal Antibodies to a Cell-Surface Glycoprotein

1985 • 217 citations

Characterization of a human melanoma-associated ganglioside antigen defined by a monoclonal antibody, 4.2.

1982 • 217 citations

Activation of (Na⁺, K⁺)‐ATPase by Nanomolar Concentrations of GM₁ Ganglioside

1981 • 212 citations

Promotion of Neuritogenesis in Mouse Neuroblastoma Cells by Exogenous Gangliosides. Relationship Between the Effect and the Cell Association of Ganglioside GM₁

1984 • 209 citations

Monoclonal IgM in a patient with paraproteinemic polyneuropathy binds to gangliosides containing disialosyl groups

1985 • 184 citations

Calcium/Ganglioside‐Dependent Protein Kinase Activity in Rat Brain Membrane

1985 • 170 citations

GM3 ganglioside induces hamster fibrobiast growth inhibition in chemically-defined medium: Ganglioside may regulate growth factor receptor function

1982 • 164 citations

Incorporation of ganglioside analogs into fibroblast cell membranes. A spin-label study

1983 • 153 citations

Interaction of choleragen with the oligosaccharide of ganglioside GM1: evidence for multiple oligosaccharide Binding sites

1978 • 145 citations

Rabbit intestinal glycoprotein receptor for Escherichia coli heat-labile enterotoxin lacking affinity for cholera toxin

1982 • 144 citations

Effect of gangliosides on adenylate cyclase activity in rat cerebral cortical membranes.

1979 • 144 citations

A review of the immunogenic and immuno-modulatory properties of glycosphingolipids

1984 • 140 citations

Exogenous glycosphingolipids suppress growth rate of transformed and untransformed 3T3 mouse cells

1975 • 135 citations

Monoclonal antibody A2B5 reacts with many gangliosides in neuronal tissue

1984 • 125 citations

Characterization of the Cellular Binding of Exogenous Gangliosides

1977 • 117 citations

The monoclonal antibody A2B5 is specific to ganglioside GQ1c

1983 • 112 citations

Direct Evidence That Endogenous G _M1 Ganglioside Can Mediate Thymocyte Proliferation

1985 • 110 citations

The suppressive effect of gangliosides upon IL 2-dependent proliferation as a function of inhibition of IL 2-receptor association.

1986 • 105 citations

Uptake and metabolism of gangliosides in transformed mouse fibroblasts. Relationship of ganglioside structure to choleragen response.

1976 • 105 citations

Ganglioside GD2 specificity of monoclonal antibodies to human neuroblastoma cell

1985 • 102 citations

Direct visualization of redistribution and capping of fluorescent gangliosides on lymphocytes.

1984 • 94 citations

Exogenous gangliosides enhance the interaction of fibronectin with ganglioside-deficient cells

1983 • 91 citations

Localization of the ganglioside-binding site of fibronectin.

1986 • 91 citations

Inhibition of the lectin-induced mitogenic response of thymocytes by glycolipids.

1979 • 85 citations

Biosynthesis and localization of gangliosides in cultured cells

1982 • 85 citations

Mechanism of action of cholera toxin: Studies on the lag period

1980 • 82 citations

Characterization of the receptor for cholera toxin and Escherichia coli heat-labile toxin in rabbit intestinal brush borders

1986 • 82 citations

Gangliosides as receptors for fibronectin?

1982 • 80 citations

Characterization of tetanus toxin binding to rat brain membranes. Evidence for a high-affinity proteinase-sensitive receptor

1986 • 79 citations

Interaction of cholera toxin with rat intestinal brush border membranes. Relative roles of gangliosides and galactoproteins as toxin receptors.

1981 • 75 citations

Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin.

1984 • 72 citations

Escherichia coli heat-labile enterotoxin. Ganglioside specificity and ADP-ribosyltransferase activity.

1981 • 69 citations

Tetanus toxin receptors on nerve cells contain a trypsin-sensitive component

1986 • 64 citations

Modification of ganglioside GM1. Effect of lipid moiety on choleragen action.

1980 • 64 citations

Reevaluation of the Role of Gangliosides as Receptors for Tetanus Toxin

1986 • 60 citations

Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells.

1985 • 57 citations

Monoclonal antibody 18B8, which detects synapse-associated antigens, binds to ganglioside GT3 (II3 (NeuAc)3LacCer).

1986 • 57 citations

Fate of tetanus toxin bound to the surface of primary neurons in culture: evidence for rapid internalization.

1985 • 57 citations

Fibrillar organization of fibronectin is expressed coordinately with cell surface gangliosides in a variant murine fibroblast.

1986 • 52 citations

Escherichia coli heat-labile enterotoxin. Ganglioside specificity and ADP-ribosyltransferase activity.

1981 • 52 citations

Receptor ganglioside content of three hosts for sendai virus: MDBK, HeLa, and MDCK Cells

1984 • 52 citations

Gangliosides sensitize unresponsive fibroblasts to Escherichia coli heat-labile enterotoxin.

1979 • 51 citations

Characteristics of angiotensin II binding sites in the neostriatum of the rat brain

1982 • 50 citations

Effect of serum on ganglioside uptake and choleragen responsiveness of transformed mouse fibroblasts

1978 • 38 citations

Lipolytic action of cholera toxin on fat cells. Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor.

1976 • 36 citations

The role of gangliosides in the interaction of human chorionic gonadotropin and cholera toxin with murine Leydig tumor cells.

1984 • 19 citations

Variants of BALB/c 3T3 cells lacking complex gangliosides retain a fibronectin matrix and spread normally on fibronectin-coated substrates.

1986 • 18 citations