Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

The MAPK signaling cascade

1995 • 3,300 citations

Protein modules and signalling networks

1995 • 2,447 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

The ins and outs of Raf kinases

1994 • 537 citations

Comparison of a Structural and a Functional Epitope

1993 • 512 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Quantitative Analysis of the Complex between p21 and the Ras-binding Domain of the Human Raf-1 Protein Kinase

1995 • 348 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

High resolution functional analysis of antibody-antigen interactions

1992 • 213 citations

Rational design of receptor-specific variants of human growth hormone.

1991 • 204 citations

Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

1995 • 202 citations

Gene regulation by Ets proteins

1993 • 199 citations

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.

1988 • 196 citations

The effector interactions of p21ras

1993 • 193 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.

1994 • 185 citations

GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

1993 • 180 citations

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.

1994 • 175 citations

Thermodynamic analysis of an antibody functional epitope

1993 • 169 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

Regulation of Raf-1 and Raf-1 Mutants by Ras-Dependent and Ras-Independent Mechanisms In Vitro

1995 • 140 citations

Pharmaceutical research in molecular oncology

1994 • 134 citations

Improved method for PCR-mediated site-directed mutagenesis

1994 • 120 citations

Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

1990 • 114 citations

Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface

1995 • 109 citations

Signal integration at the c-fos promoter

1995 • 109 citations

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase

1993 • 105 citations

Ras‐effector interactions, the problem of specificity

1995 • 89 citations

Signal transduction pathways involving RAS

1994 • 63 citations

Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP.

1994 • 58 citations

Isolation and characterization of temperature-sensitive mutations in RPA190, the gene encoding the largest subunit of RNA polymerase I from Saccharomyces cerevisiae.

1988 • 55 citations

Identification of the sites of interaction between c-Raf-1 and Ras-GTP.

1995 • 55 citations

Identification of amino acid residues required for Ras p21 target activation.

1991 • 53 citations

The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype.

1994 • 45 citations

Chemical Shift Assignments and Folding Topology of the RAS-Binding Domain of Human RAF-1 As Determined by Heteronuclear Three-Dimensional NMR Spectroscopy

1994 • 38 citations

Switching to Rac and Rho

1995 • 8 citations