Prolongation of Survival of Mice with Glioma Treated with Semiallogeneic Fibroblasts Secreting Interleukin-2

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Treatment of 283 Consecutive Patients With Metastatic Melanoma or Renal Cell Cancer Using High-Dose Bolus Interleukin 2

1994 • 1,070 citations

A new dominant hybrid selective marker for higher eukaryotic cells

1981 • 662 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

Intratumoral LAK cell and interleukin-2 therapy of human gliomas

1989 • 252 citations

Modulation of T-cell function by gliomas

1991 • 241 citations

Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice.

1992 • 182 citations

Rejection of mouse sarcoma cells after transfection of MHC class II genes.

1990 • 171 citations

Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene.

1988 • 110 citations

RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma.

1995 • 107 citations

Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.

1987 • 103 citations

In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors

1994 • 87 citations

Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes

1990 • 80 citations

Tumor rejection mediated by transfection with allogeneic class I histocompatibility gene.

1989 • 76 citations

Treatment of recurrent malignant glioma by repeated intracerebral injections of human recombinant interleukin-2 alone or in combination with systemic interferon-?. Results of a phase I clinical trial

1992 • 75 citations

Prolonged survival of mice with glioma injected intracerebrally with double cytokine—secreting cells

1995 • 70 citations

Efficient direct priming of tumor-specific cytotoxic T lymphocyte in vivo by an engineered APC.

1998 • 68 citations

Fibroblasts Genetically Engineered to Secrete Cytokines Suppress Tumor Growth and Induce Antitumor Immunity to a Murine Glioma In Vivo

1995 • 59 citations

Intracerebral versus Subcutaneous Immunization with Allogeneic Fibroblasts Genetically Engineered to Secrete Interleukin-2 in the Treatment of Central Nervous System Glioma and Melanoma

1997 • 55 citations

Histopathological and blood-brain barrier changes in rats induced by an intracerebral injection of human recombinant interleukin 2

1989 • 53 citations

Immunity to B16 melanoma in mice immunized with IL‐2‐secreting allogeneic mouse fibroblasts expressing melanoma‐associated antigens

1992 • 44 citations

Histopathological and Blood-Brain Barrier Changes in Rats Induced by an Intracerebral Injection of Human Recombinant Interleukin 2

1989 • 35 citations

Resistance to melanoma in mice immunized with semiallogeneic fibroblasts transfected with DNA from mouse melanoma cells.

1998 • 24 citations

Resistance to Melanoma in Mice Immunized with Semiallogeneic Fibroblasts Transfected with DNA from Mouse Melanoma Cells

1998 • 20 citations

Survival and Toxicity of an Allogeneic Cytokine-secreting Fibroblast Vaccine in the Central Nervous System

1998 • 18 citations