Survival and Toxicity of an Allogeneic Cytokine-secreting Fibroblast Vaccine in the Central Nervous System

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Treatment of 283 Consecutive Patients With Metastatic Melanoma or Renal Cell Cancer Using High-Dose Bolus Interleukin 2

1994 • 1,070 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

Unraveling Immune Privilege

1995 • 302 citations

Intratumoral LAK cell and interleukin-2 therapy of human gliomas

1989 • 252 citations

Rejection of mouse sarcoma cells after transfection of MHC class II genes.

1990 • 171 citations

Treatment of glioma by engineered interleukin 4-secreting cells.

1993 • 149 citations

Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene.

1988 • 110 citations

RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma.

1995 • 107 citations

Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.

1987 • 103 citations

In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors

1994 • 87 citations

Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes

1990 • 80 citations

Tumor rejection mediated by transfection with allogeneic class I histocompatibility gene.

1989 • 76 citations

Treatment of recurrent malignant glioma by repeated intracerebral injections of human recombinant interleukin-2 alone or in combination with systemic interferon-?. Results of a phase I clinical trial

1992 • 75 citations

Prolonged survival of mice with glioma injected intracerebrally with double cytokine—secreting cells

1995 • 70 citations

Treatment of murine primary brain tumors with systemic interleukin-2 and tumor-infiltrating lymphocytes

1992 • 51 citations

MANIPULATION OF METASTASIS AND TUMOUR GROWTH BY TRANSFECTION WITH HISTOCOMPATIBILITY CLASS I GENES

1986 • 47 citations

Immunity to B16 melanoma in mice immunized with IL‐2‐secreting allogeneic mouse fibroblasts expressing melanoma‐associated antigens

1992 • 44 citations

Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT).

1988 • 26 citations

Immunity to melanoma in mice immunized with transfected allogeneic mouse fibroblasts expressing melanoma-associated antigens

1991 • 6 citations