Classification of Breast Cancer Using Genetic Algorithms and Tissue Microarrays

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

An Introduction to Genetic Algorithms

1996 • 11,007 citations

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

2004 • 5,895 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma

2004 • 2,644 citations

Breast cancer classification and prognosis based on gene expression profiles from a population-based study

2003 • 2,013 citations

Predicting the clinical status of human breast cancer by using gene expression profiles

2001 • 1,336 citations

Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

2002 • 1,114 citations

Analysis of Microarray Data Using Z Score Transformation

2003 • 992 citations

A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

2004 • 941 citations

Automated subcellular localization and quantification of protein expression in tissue microarrays

2002 • 764 citations

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns.

2001 • 672 citations

Expression of luminal and basal cytokeratins in human breast carcinoma

2004 • 593 citations

Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer.

1997 • 409 citations

The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1 -Related Breast Cancer

2004 • 367 citations

Molecular cytogenetics of primary breast cancer by CGH

1998 • 362 citations

Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations.

1997 • 362 citations

Comparative genomic hybridization of ductal carcinomain situ of the breast?evidence of multiple genetic pathways

1999 • 334 citations

Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells.

2001 • 304 citations

Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer.

1995 • 302 citations

Discovery of estrogen receptor α target genes and response elements in breast tumor cells

2004 • 300 citations

Development of cDNA microarray for expression profiling of estrogen-responsive genes

2002 • 293 citations

Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.

2000 • 284 citations

Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis

2005 • 275 citations

Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.

1991 • 272 citations

Molecular markers in ductal carcinoma in situ of the breast.

2003 • 268 citations

Genetic algorithms applied to multi-class prediction for the analysis of gene expression data

2002 • 263 citations

Effects of estrogen on global gene expression: identification of novel targets of estrogen action.

2000 • 258 citations

Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer.

1999 • 241 citations

Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer.

1999 • 235 citations

Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer.

2003 • 231 citations

Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors.

2003 • 231 citations

Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas.

1995 • 230 citations

Protein Expression Profiling Identifies Subclasses of Breast Cancer and Predicts Prognosis

2005 • 215 citations

Hierarchical Clustering Analysis of Tissue Microarray Immunostaining Data Identifies Prognostically Significant Groups of Breast Carcinoma

2004 • 206 citations

Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome.

2003 • 204 citations

Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.

2003 • 194 citations

GATA-3 is expressed in association with estrogen receptor in breast cancer

1999 • 185 citations

Novel Prognostic Immunohistochemical Biomarker Panel for Estrogen Receptor–Positive Breast Cancer

2006 • 181 citations

Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas

1998 • 175 citations

Molecular Classification of Breast Carcinomas Using Tissue Microarrays

2003 • 170 citations

cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells

2003 • 165 citations

Genetic alterations in lobular breast cancer by comparative genomic hybridization

1997 • 159 citations

Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma

1999 • 156 citations

Gene Expression Profiling of Breast Cancer: A New Tumor Marker

2005 • 154 citations

Quantitative Determination of Expression of the Prostate Cancer Protein α-Methylacyl-CoA Racemase Using Automated Quantitative Analysis (AQUA)

2004 • 150 citations

hAG-2, the Human Homologue of theXenopus laevisCement Gland Gene XAG-2, Is Coexpressed with Estrogen Receptor in Breast Cancer Cell Lines

1998 • 150 citations

Analysis of the phosphofructokinase subunits and isoenzymes in human tissues

1988 • 148 citations

Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer.

2002 • 147 citations

Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma

2003 • 143 citations

Gene expression profiles of poor-prognosis primary breast cancer correlate with survival

2002 • 131 citations

Linking gene expression patterns to therapeutic groups in breast cancer.

2000 • 122 citations

Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping

2000 • 121 citations

Two years of adjuvant tamoxifen in premenopausal patients with breast cancer: a randomised, controlled trial with long-term follow-up

2004 • 117 citations

What's going on 乳癌 A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Ma XJ, Wang Z, Ryan PD, Isakoff SJ, Barmettler A, Fuller A, et al. Cancer Cell. 2004;5:607-16. PMID:15193263--術後補助療法におけるタモキシフェンへの反応性は2つの遺伝子レベルの測定によって予測しうることを示した論文

2005 • 116 citations

Tissue microarray analysis of neuroendocrine differentiation and its prognostic significance in breast cancer

2003 • 116 citations

Macrophage Colony-Stimulating Factor-1 Receptor Expression Is Associated with Poor Outcome in Breast Cancer by Large Cohort Tissue Microarray Analysis

2004 • 112 citations

Differential Gene Expression Patterns in HER2/neu-Positive and -Negative Breast Cancer Cell Lines and Tissues

2002 • 107 citations

NHE-RF, a Merlin-Interacting Protein, Is Primarily Expressed in Luminal Epithelia, Proliferative Endometrium, and Estrogen Receptor-Positive Breast Carcinomas

2001 • 102 citations

Tissue microarray‐based studies of patients with lymph node negative breast carcinoma show that met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors

2003 • 99 citations

Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells

1999 • 98 citations

Detection of circulating breast tumor cells by differential expression of marker genes.

2002 • 94 citations

A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome

2004 • 87 citations

Discovery of differentially expressed genes in human breast cancer using subtracted cDNA libraries and cDNA microarrays

2002 • 86 citations

Genetic changes in breast cancer detected by comparative genomic hybridisation

2000 • 81 citations

Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder.

1996 • 80 citations

Identification of amplified and expressed genes in breast cancer by comparative hybridization onto microarrays of randomly selected cDNA clones

2002 • 78 citations

β‐Catenin and p53 analyses of a breast carcinoma tissue microarray

2004 • 77 citations

Letrozole-, Anastrozole-, and Tamoxifen-Responsive Genes in MCF-7aro Cells: A Microarray Approach

2005 • 76 citations

Molecular classification of breast cancer patients by gene expression profiling*

2001 • 75 citations

Genetic analysis of 53 lymph node-negative breast carcinomas by CGH and relation to clinical, pathological, morphometric, and DNA cytometric prognostic factors

1998 • 72 citations

Molecular classification of primary breast tumors possessing distinct prognostic properties

2002 • 62 citations

Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q

1998 • 57 citations

Characterization of human cellular gamma-glutamyl hydrolase.

1998 • 47 citations

Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas

2002 • 45 citations

Tissue microarray study for classification of breast tumors

2003 • 45 citations

Characterization of the novel amplified in breast cancer-1 (NABC1) gene product

2003 • 34 citations

A Novel Approach to the Characterization of Substrate Specificity in Short/Branched Chain Acyl-CoA Dehydrogenase

2003 • 32 citations

Coexpression of β1,6-N-Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome

2005 • 32 citations

Prediction of hormone sensitivity by DNA microarray

2003 • 18 citations