Nuclear Targeting of Macromolecular Polyanions by an HIV-Tat Derived Peptide

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

Functions of Cell Surface Heparan Sulfate Proteoglycans

1999 • 2,660 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

1997 • 2,291 citations

Proteoglycans: Structures And Interactions

1991 • 1,596 citations

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

1988 • 1,488 citations

Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate

2002 • 1,437 citations

A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry

1999 • 1,019 citations

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

2001 • 773 citations

Evidence for the role of proteoglycans in cation-mediated gene transfer.

1996 • 765 citations

Trojan peptides: the penetratin system for intracellular delivery

1998 • 707 citations

Internalization of HIV-1 Tat Requires Cell Surface Heparan Sulfate Proteoglycans

2001 • 707 citations

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

1999 • 672 citations

Animal cell mutants defective in glycosaminoglycan biosynthesis.

1985 • 587 citations

Endocytosis and targeting of exogenous HIV-1 Tat protein.

1991 • 481 citations

Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

2000 • 370 citations

Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters

2000 • 360 citations

Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1

1991 • 305 citations

Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.

1992 • 299 citations

Protein Transduction Domain of HIV-1 Tat Protein Promotes Efficient Delivery of DNA into Mammalian Cells

2001 • 284 citations

Binding of syndecan-like cell surface proteoglycan receptors is required for Neisseria gonorrhoeae entry into human mucosal cells.

1995 • 240 citations

Regulation of HIV‐1 gene expression

1991 • 234 citations

Expression of naked DNA in human, pig, and mouse skin.

1996 • 198 citations

Interaction of HIV-1 Tat Protein with Heparin

1997 • 194 citations

Noninvasive intracellular delivery of functional peptides and proteins

1999 • 147 citations

Glypican and Biglycan in the Nuclei of Neurons and Glioma Cells: Presence of Functional Nuclear Localization Signals and Dynamic Changes in Glypican During the Cell Cycle

1997 • 128 citations

Tumor attenuation by combined heparan sulfate and polyamine depletion

2001 • 119 citations

Perlecan Heparan Sulfate Proteoglycan

2000 • 119 citations

Multiple Interactions of HIV-I Tat Protein with Size-defined Heparin Oligosaccharides

1999 • 118 citations

Accumulation of β‐amyloid precursor protein in HIV encephalitis: Relationship with neuropsychological abnormalities

1997 • 112 citations

Nearest neighbor analysis of heparin: identification and quantitation of the products formed by selective depolymerization procedures

1976 • 112 citations

The Basic Domain in HIV-1 Tat Protein as a Target for Polysulfonated Heparin-mimicking Extracellular Tat Antagonists

1998 • 111 citations

The Potential Role of Proteoglycans in Cationic Lipid-mediated Gene Delivery

2001 • 105 citations

Proteoglycan involvement in polyamine uptake

1999 • 96 citations

Neurotoxicity of the human immunodeficiency virus type 1 Tat transactivator to PC12 cells requires the Tat amino acid 49‐58 basic domain

1995 • 70 citations

Structural studies on heparan sulphates. Characterization of oligosaccharides; obtained by periodate oxidation and alkaline elimination.

1980 • 66 citations

Modulations of Glypican-1 Heparan Sulfate Structure by Inhibition of Endogenous Polyamine Synthesis

2001 • 53 citations

Intracellular Accumulation of Secreted Proteoglycans Inhibits Cationic Lipid-mediated Gene Transfer

1999 • 52 citations

Structural Studies on Heparan Sulphates

1980 • 52 citations

Protective role for proteoglycans against cationic lipid cytotoxicity allowing optimal transfection efficiency in vitro

1999 • 38 citations

Heparan sulphate/heparin glycosaminoglycans with strong affinity for the growth-promoter spermine have high antiproliferative activity

1996 • 36 citations

Differences in the uptake and nuclear localization of anti‐proliferative heparan sulfate between human lung fibroblasts and human lung carcinoma cells

2001 • 34 citations

Basic fibroblast growth factor does not prevent heparan sulphate proteoglycan catabolism in intact cells, but it alters the distribution of the glycosaminoglycan degradation products

1999 • 33 citations

The Interaction between Basic Fibroblast Growth Factor and Heparan Sulfate Can Prevent the in Vitro Degradation of the Glycosaminoglycan by Chinese Hamster Ovary Cell Heparanases

1997 • 31 citations