Studies on the Internalization Mechanism of Cationic Cell-penetrating Peptides

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

1997 • 2,291 citations

The third helix of the Antennapedia homeodomain translocates through biological membranes.

1994 • 1,964 citations

Arginine-rich Peptides

2001 • 1,582 citations

Cell-penetrating Peptides

2002 • 1,392 citations

Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent

1996 • 1,047 citations

The helical hydrophobic moment: a measure of the amphiphilicity of a helix

1982 • 1,030 citations

Why and how are peptide–lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes

1999 • 984 citations

Mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles

1974 • 949 citations

Cell-penetrating peptides

2000 • 767 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Hydrophobic parameters π of amino-acid side chains from the partitioning of N-acetyl-amino-acid amides.

1983 • 705 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Cell penetration by transportan

1998 • 621 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Receptor-mediated endocytosis of transferrin in K562 cells.

1983 • 576 citations

Protein transduction: unrestricted delivery into all cells?

2000 • 560 citations

Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

1993 • 497 citations

Cellular uptake of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

1998 • 436 citations

Possible Existence of Common Internalization Mechanisms among Arginine-rich Peptides

2002 • 429 citations

Vacuolar ATPase activity is required for endosomal carrier vesicle formation.

1994 • 418 citations

Peptide Helicity and Membrane Surface Charge Modulate the Balance of Electrostatic and Hydrophobic Interactions with Lipid Bilayers and Biological Membranes

1996 • 393 citations

Actin Assembly Plays a Variable, but not Obligatory Role in Receptor‐Mediated Endocytosis

2000 • 385 citations

New Advances in the Transport of Doxorubicin through the Blood-Brain Barrier by a Peptide Vector-Mediated Strategy

2000 • 339 citations

Effect of Bafilomycin A1 and Nocodazole on Endocytic Transport in HeLa Cells: Implications for Viral Uncoating and Infection

1998 • 325 citations

Iron Acquired from Transferrin by K562 Cells Is Delivered into a Cytoplasmic Pool of Chelatable Iron(II)

1995 • 320 citations

Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways

2001 • 319 citations

Endolysosomal proteolysis and its regulation

2002 • 298 citations

Cargo delivery kinetics of cell-penetrating peptides

2001 • 294 citations

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes.

1986 • 270 citations

The Antennapedia peptide penetratin translocates across lipid bilayers – the first direct observation

2000 • 231 citations

Positively Charged DNA-Binding Proteins Cause Apparent Cell Membrane Translocation

2002 • 231 citations

Endolysosomal proteolysis and its regulation

2002 • 216 citations

ATP is required for receptor-mediated endocytosis in intact cells.

1990 • 206 citations

Translocation of Analogues of the Antimicrobial Peptides Magainin and Buforin across Human Cell Membranes

2003 • 202 citations

Synthesis and Solution Structure of the Antimicrobial Peptide Protegrin‐1

1996 • 182 citations

Structural requirements for cellular uptake of α-helical amphipathic peptides

1999 • 163 citations

Conformational and Associative Behaviours of the Third Helix of Antennapedia Homeodomain in Membrane‐Mimetic Environments

1996 • 161 citations

Cell penetration by transportan

1998 • 159 citations

Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles

2001 • 153 citations

Enhanced delivery of doxorubicin into the brain via a peptide-vector-mediated strategy: saturation kinetics and specificity.

2001 • 148 citations

Physico‐chemical requirements for cellular uptake of pAntp peptide

2001 • 147 citations

Change in membrane permeability induced by protegrin 1: implication of disulphide bridges for pore formation

1996 • 125 citations

Doxorubicin-peptide conjugates overcome multidrug resistance

2001 • 121 citations

Membrane channel formation by antimicrobial protegrins

1999 • 117 citations

Redistribution of mannose-6-phosphate receptors induced by tunicamycin and chloroquine.

1984 • 114 citations

Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity

2002 • 107 citations

Secondary Structure and Position of the Cell-Penetrating Peptide Transportan in SDS Micelles As Determined by NMR

2001 • 107 citations

Translocation of the pAntp Peptide and Its Amphipathic Analogue AP-2AL

2001 • 105 citations

Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex.

1993 • 95 citations

Translocation Properties of Novel Cell Penetrating Transportan and Penetratin Analogues

2000 • 87 citations

Conformations of Primary Amphipathic Carrier Peptides in Membrane Mimicking Environments

1997 • 85 citations

Import of a Mitochondrial Presequence Into Protein-Free Phospholipid Vesicles

1993 • 81 citations

Improved Brain Delivery of Benzylpenicillin with a Peptide-vector-mediated Strategy

2002 • 75 citations

Designing cell-permeant phosphopeptides to modulate intracellular signaling pathways

2001 • 65 citations

Microtubule inhibitors differentially affect translational movement, cell surface expression, and endocytosis of transferrin receptors in K562 cells

1994 • 62 citations

Translocation of protegrin I through phospholipid membranes: role of peptide folding

2002 • 39 citations

Interactions of Primary Amphipathic Vector Peptides with Membranes. Conformational Consequences and Influence on Cellular Localization

1998 • 33 citations

Influence of conjugation of doxorubicin to transferrin on the iron uptake by K562 cells via receptor‐mediated endocytosis

1993 • 28 citations