Modulation of interleukin-6 expression in Hodgkin and Reed-Sternberg cells by Epstein-Barr virus

The biology of interleukin-6

1989 • 1,964 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

The biology of interleukin-6

1989 • 1,459 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.

1987 • 735 citations

Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease

1991 • 718 citations

Expression of Epstein‐Barr virus‐encoded proteins in nasopharyngeal carcinoma

1988 • 447 citations

Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells.

1991 • 415 citations

Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines

1995 • 212 citations

Identification of interleukin-6 as an autocrine growth factor for Epstein-Barr virus-immortalized B cells

1990 • 211 citations

Use of freeze-dried paraffin-embedded sections for immunohistologic staining with monoclonal antibodies.

1985 • 208 citations

Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers

1994 • 207 citations

Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease

1996 • 193 citations

Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency.

1993 • 182 citations

Distribution and phenotype of Epstein-Barr virus-harboring cells in Hodgkin's disease

1992 • 179 citations

Serum interleukin 6 levels are elevated in lymphoma patients and correlate with survival in advanced Hodgkin's disease and with B symptoms.

1993 • 169 citations

Interleukin-6 immunoreactivity in human tumors.

1989 • 136 citations

Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease

1991 • 133 citations

Lymphotoxin, tumour necrosis factor and interleukin‐6 gene transcripts are present in Hodgkin and Reed‐Sternberg cells of most Hodgkin's disease cases

1993 • 105 citations

Expression of an exogenous interleukin 6 gene in human Epstein Barr virus B cells confers growth advantage and in vivo tumorigenicity.

1990 • 105 citations

In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease

1994 • 102 citations

Patterns of cytokine gene expression in infectious mononucleosis

1994 • 88 citations

Interleukin 4 is at 5q31 and interleukin 6 is at 7p15

1988 • 82 citations

Transcriptional regulation of the human interleukin-6 gene promoter in human T-cell leukemia virus type I-infected T-cell lines: evidence for the involvement of NF-kappa B

1994 • 75 citations

In vitrotranscription of two Epstein-Barr virus specified small RNA molecules

1982 • 62 citations

Soluble Interleukin 6 Receptor is Biologically Active In Vivo

1995 • 57 citations

Hodgkin's Disease: A Cytokine-Producing Tumor − A Review

1994 • 45 citations

A longitudinal study of patients with hemophilia: immunologic correlates of infection with HTLV-III/LAV and other viruses

1985 • 39 citations

PHENOTYPIC MODULATION OF HODGKIN AND REED-STERNBERG CELLS BY EPSTEIN-BARR VIRUS

1996 • 35 citations

Increased levels of circulating interleukin‐6 in patients with hodgkin's disease

1991 • 34 citations

Specificity of riboprobes for intracellular RNA in hybridization histochemistry.

1988 • 20 citations