Evidence for Substance P as an Endogenous Substance Causing Cough in Guinea Pigs

Handbook of Physiology.

1960 • 10,428 citations

The Respiratory System

1983 • 1,825 citations

Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

1977 • 1,284 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

The sensory-efferent function of capsaicin-sensitive sensory neurons

1988 • 935 citations

ANGIOTENSIN-CONVERTING ENZYME AND THE COUGH REFLEX

1987 • 744 citations

Afferent vagal C fibre innervation of the lungs and airways and its functional significance

1984 • 714 citations

Tachykinins

1988 • 542 citations

Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man

1984 • 512 citations

Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants

1983 • 495 citations

Receptors in the trachea and bronchi of the cat

1954 • 471 citations

The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11

1984 • 376 citations

Afferent neural pathways in cough and reflex bronchoconstriction

1988 • 372 citations

Respiratory Defense Mechanisms.

1978 • 330 citations

Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals.

1989 • 248 citations

Cough associated with captopril and enalapril.

1987 • 209 citations

Stimulation of ‘irritant’ receptors and afferent C-fibres in the lungs by prostaglandins

1976 • 186 citations

Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea.

1987 • 180 citations

Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS

1984 • 164 citations

Cough Associated With the Use of Captopril

1985 • 161 citations

Pharmacological profile of a high affinity dipeptide NK₁ receptor antagonist, FK888

1992 • 146 citations

Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs.

1988 • 127 citations

Influence of Lung Stretch Receptors on the Cough Reflex in Rabbits

1984 • 116 citations

Sensory transmitters regulate intracellular calcium in dorsal horn neurons

1988 • 115 citations

Neuropeptides degranulate serous cells of ferret tracheal glands

1986 • 106 citations

Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung.

1987 • 105 citations

Nonpeptide antagonists herald new era in tachykinin research

1992 • 85 citations

Effect of Antitussive Agents on Experimental and Pathological Cough in Man

1954 • 67 citations

Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerve stimulation in guinea pigs.

1992 • 65 citations

Respiratory reflexes and defense

1977 • 36 citations

A Method for Determining the Cough Threshold with Some Preliminary Experiments on the Effect of Codeine

1950 • 35 citations

Role of the vagal afferents in substance P‐induced respiratory responses in anaesthetized rabbits

1987 • 30 citations

Influence of nicotine in cigarette smoke on acute ventilatory responses in awake dogs

1985 • 21 citations

Capsaicin Desensitization Inhibits Cigarette Smoke-induced Increase in Cytoplasmic Motility of Alveolar Macrophages in Guinea Pigs

1992 • 6 citations